Mesenchymal Stem Cells: From Regeneration to Drug Delivery Systems.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2021033916

Zeeshan Shokat, Abdaal Ali, Uzair Ahmed, Muhammad Rizwan Javed, Muhammad Qasim, Muhammad Tariq, Muhammad Rauf Ahmed, Muhammad Shareef Masoud

引用次数: 3

Abstract

Targeting drug delivery has been a focus of researchers in recent years for cancer and other diseases. Many approaches such as liposomes, exosomes, nanoparticles (magnetic), encapsulation etc. have been developed and investigated for their clinical applications. But disadvantages linked to these therapies limit them to be used in clinical settings. Cell based drug delivery systems has emerged as an alternative for these therapies. Among cell types, mesenchymal stem cells (MSCs) proved to a potential cell type for research due to its many characteristics including low immunogenicity, chemotaxis and homing to tumor sites which are considered mandatory for drug delivery. This chapter focuses on the challenges and opportunities in using MSCs as therapeutic carrier of drugs in different ailments.

查看原文本刊更多论文

间充质干细胞:从再生到药物输送系统。

靶向给药是近年来癌症和其他疾病研究人员关注的焦点。许多方法如脂质体、外泌体、纳米颗粒(磁性)、包封等已被开发和研究用于临床应用。但是与这些疗法相关的缺点限制了它们在临床环境中的应用。基于细胞的药物输送系统已经成为这些疗法的替代方案。在细胞类型中，间充质干细胞(MSCs)被证明是一种潜在的研究细胞类型，因为它具有许多特性，包括低免疫原性、趋化性和归巢到肿瘤部位，这些被认为是药物传递所必需的。本章重点介绍了利用间充质干细胞作为药物治疗载体治疗不同疾病的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.