The role of connexins in breast cancer: from misregulated cell communication to aberrant intracellular signaling.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-08-06 DOI:10.1080/21688370.2021.1962698

Yagmur Ceren Unal, Busra Yavuz, Engin Ozcivici, Gulistan Mese

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Abstract

In spite of clinical advancements and improved diagnostic techniques, breast cancers are the leading cause of cancer-associated deaths in women worldwide. Although 70% of early breast cancers can be cured, there are no efficient therapies against metastatic breast cancers. Several factors including connexins and gap junctions play roles in breast tumorigenesis. Connexins are critical for cellular processes as a linkage between connexin mutations and hereditary disorders demonstrated their importance for tissue homeostasis. Further, alterations in their expression, localization and channel activities were observed in many cancers including breast cancer. Both channel-dependent and independent functions of connexins were reported in initiation and progression of cancers. Unlike initial reports suggesting tumor suppressor functions, connexins and gap junctions have stage, context and isoform dependent effects in breast cancers similar to other cancers. In this review, we tried to describe the current understanding of connexins in tumorigenesis specifically in breast cancers.

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附件蛋白在乳腺癌中的作用：从失调的细胞通讯到异常的细胞内信号传导。

尽管临床研究取得了进展，诊断技术也得到了改进，但乳腺癌仍然是全球妇女因癌症死亡的主要原因。虽然 70% 的早期乳腺癌可以治愈，但目前还没有针对转移性乳腺癌的有效疗法。包括连接蛋白和间隙连接在内的一些因素在乳腺癌的发生中起着作用。附件蛋白对细胞过程至关重要，因为附件蛋白突变与遗传性疾病之间的联系证明了它们对组织稳态的重要性。此外，在包括乳腺癌在内的许多癌症中都观察到了其表达、定位和通道活性的改变。据报道，在癌症的发生和发展过程中，连接蛋白既有依赖通道的功能，也有独立的功能。与最初报道的肿瘤抑制功能不同，附件蛋白和间隙连接在乳腺癌中的作用与其他癌症类似，具有阶段、环境和同工酶依赖性。在这篇综述中，我们试图描述目前对连接蛋白在肿瘤发生（尤其是乳腺癌）中作用的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.