The Efficacy and Safety of Chitosan on Facial Skin Sebum.

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2022-01-01 Epub Date: 2021-06-23 DOI:10.1159/000517965

Chinathip Theerawattanawit, Punnawich Phaiyarin, Supason Wanichwecharungruang, Nopadon Noppakun, Pravit Asawanonda, Chanat Kumtornrut

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引用次数: 4

Abstract

Introduction: Seborrhea or oily skin has been one of the most common complaints affecting both men and women physically and psychologically. Chitosan is a biopolymer obtained from the alkaline deacetylation of chitin. Due to its positively charged nature, chitosan can effectively bind to lipids. Therefore, chitosan nanoparticle (CN) formulation may benefit in the reduction of skin sebum.

Objective: The aim of this study was to evaluate the efficacy and safety of CN formulation in the reduction of skin sebum.

Method: The study was a randomized, double-blinded, placebo-controlled trial in 24 participants aged 18-40 years with clinical seborrhea. Participants were randomly assigned to apply the CN and gum (CN-G) or placebo (gum alone) twice daily for 4 weeks. Sebum level, corneometry, transepidermal water loss (TEWL), and clinical seborrhea grading were evaluated at baseline and week 2 and 4.

Results: In the T-zone, sebum levels in the CN-G group were significantly lower than the placebo group at week 4 (p = 0.043), while for the U-zone, sebum levels were not different between groups. There were no statistical differences in corneometry and TEWL at any visit. Although the clinical seborrhea grading in CN-G was lower, it was not significantly different from the placebo. A few cases reported mild and self-limiting scaling and acneiform eruption.

Conclusion: The CN-G gel could significantly reduce sebum levels on seborrhea patients with acceptable safety profiles.

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壳聚糖对面部皮肤皮脂的疗效和安全性。

皮脂漏或油性皮肤一直是影响男性和女性身体和心理的最常见的抱怨之一。壳聚糖是由几丁质的碱性去乙酰化反应得到的生物聚合物。由于其带正电荷的性质，壳聚糖可以有效地与脂质结合。因此，壳聚糖纳米颗粒(CN)配方可能有利于皮肤皮脂的减少。目的:评价CN制剂对皮肤皮脂减少的疗效和安全性。方法:该研究是一项随机、双盲、安慰剂对照试验，24名年龄在18-40岁的临床脂溢症患者。参与者被随机分配使用CN和口香糖(CN- g)或安慰剂(单独口香糖)，每天两次，持续4周。在基线和第2周和第4周评估皮脂水平、角膜测量、经皮失水(TEWL)和临床皮脂漏分级。结果:在t区，CN-G组的皮脂水平在第4周显著低于安慰剂组(p = 0.043)，而在u区，两组之间的皮脂水平没有差异。在任何一次访问中，测角术和TEWL均无统计学差异。虽然CN-G组的临床脂溢症分级较低，但与安慰剂组没有显著差异。少数病例报告轻度和自限性鳞屑和痤疮样的爆发。结论:CN-G凝胶可显著降低皮脂漏患者的皮脂水平，安全性可接受。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.