Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate.

IF 1.6 4区心理学 Q3 PSYCHOLOGY

Developmental Neuropsychology Pub Date : 2021-07-01 Epub Date: 2021-08-04 DOI:10.1080/87565641.2021.1946691

Emily Kuhlmann, Ellen van der Plas, Eric Axelson, Amy L Conrad

引用次数: 2

Abstract

The present study evaluated brain development in persons with isolated cleft lip and/or cleft palate (iCL/P) compared to unaffected controls using an accelerated longitudinal design. A sample of 134 males and females, ages 7-27 years, with iCL/P (184 observations, total) was compared to 144 unaffected controls (208 evaluations, total) on Wechsler Index scores and volumetric data from structural MRI scans. Boys with isolated cleft palate had verbal IQ 15.5 points lower than perceptual IQ; a clinically significant difference. Participants with iCL/P had differential growth trajectories of regional cerebrum matter and consistently lower volumes of cerebellar gray matter and subcortical matter.

Abstract Image

查看原文本刊更多论文

孤立性唇裂和/或腭裂儿童和青年的脑发育轨迹。

本研究使用加速纵向设计评估孤立性唇裂和/或腭裂(iCL/P)患者与未受影响的对照组相比的大脑发育情况。134名男性和女性，年龄7-27岁，患有iCL/P(共184次观察)与144名未受影响的对照组(共208次评估)比较韦氏指数评分和结构MRI扫描的体积数据。孤立性腭裂男孩言语智商比知觉智商低15.5分;具有临床意义的差异。患有iCL/P的参与者具有不同的区域脑物质生长轨迹，并且小脑灰质和皮层下物质的体积始终较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Developmental Neuropsychology 医学-心理学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Devoted to exploring relationships between brain and behavior across the life span, Developmental Neuropsychology publishes scholarly papers on the appearance and development of behavioral functions, such as language, perception, and social, motivational and cognitive processes as they relate to brain functions and structures. Appropriate subjects include studies of changes in cognitive function—brain structure relationships across a time period, early cognitive behaviors in normal and brain-damaged children, plasticity and recovery of function after early brain damage, the development of complex cognitive and motor skills, and specific and nonspecific disturbances, such as learning disabilities, mental retardation, schizophrenia, stuttering, and developmental aphasia. In the gerontologic areas, relevant subjects include neuropsychological analyses of normal age-related changes in brain and behavioral functions, such as sensory, motor, cognitive, and adaptive abilities; studies of age-related diseases of the nervous system; and recovery of function in later life. Empirical studies, research reviews, case reports, critical commentaries, and book reviews are featured in each issue. By publishing both basic and clinical studies of the developing and aging brain, the journal encourages additional scholarly work that advances understanding of the field of lifespan developmental neuropsychology.