Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2022-01-01 Epub Date: 2021-06-23 DOI:10.1159/000517930

Sayed-Hamidreza Mozhgani, Farid Rajabi, Mohsen Qurbani, Yousef Erfani, Somayeh Yaslianifard, Azam Moosavi, Kiomars Pourrostami, Ali Baradaran Bagheri, Alireza Soleimani, Farida Behzadian, Mahshid Safavi, Farhad Rezaei

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引用次数: 6

Abstract

Introduction: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021.

Methods: The literature search was based on keywords including "chronic fatigue syndrome and HHV 6," "chronic fatigue syndrome and HHV-6," "chronic fatigue syndrome and HHV6," "chronic fatigue syndrome and Herpes virus 6," and "chronic fatigue syndrome and Herpesvirus6" in MEDLINE (PubMed), Web of Science, and EMBASE.

Results: The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies.

Discussion: In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.

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人类疱疹病毒6型感染与慢性疲劳综合征的风险:一项系统综述和荟萃分析

慢性疲劳综合征(CFS)是一种伴有过度疲劳或疲倦的神经系统疾病。有几份报告证实了人类疱疹病毒6型(HHV-6)感染与慢性疲劳综合症之间的联系。本系统综述和荟萃分析纳入了截至2021年5月已发表的有关该关联的研究信息。方法:基于MEDLINE (PubMed)、Web of Science、EMBASE中的关键词“慢性疲劳综合征与HHV-6”、“慢性疲劳综合征与HHV-6”、“慢性疲劳综合征与HHV6”、“慢性疲劳综合征与疱疹病毒6”、“慢性疲劳综合征与疱疹病毒6”进行文献检索。结果:文献检索确定了17项研究纳入系统评价，11项研究纳入荟萃分析。对称漏斗图和Egger检验(p值= 0.2)未发现研究间存在发表偏倚。此外，低水平的I2显示了研究的同质性。讨论:总之，HHV-6感染与CFS发病率之间的关联得到了证实。然而，这项研究的结果也表明，需要进一步的全面研究来巩固HHV-6与CFS之间的联系。未来的研究应考虑可能影响这种相关性重要性的其他因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.