Correlation of serum ferritin levels with neurological function-related indices and cognitive dysfunction in patients with cerebral hemorrhage.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2021-11-01 DOI:10.5414/NP301368

Tian-Ye Lan, Da-Yong Cui, Ting-Ting Liu, Jian-Yu Pan, Xin Wang

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引用次数: 2

Abstract

Aims: The purpose of this study was to explore the correlation of serum ferritin (FS) levels with neurological function-related indices, such as neuron-specific enolase (NSE) and S100β protein levels, and cognitive dysfunction in patients with cerebral hemorrhage.

Materials and methods: Patients with acute non-traumatic cerebral hemorrhage (cerebrovascular disease (VD), n = 128) and healthy controls (CON, n = 128) were included. FS, NSE, and S100β levels were measured using ELISA. Cognitive functions were evaluated using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). The receiver operating characteristic (ROC) curve was used to assess the ability of SE, NSE, and serum S100β to predict the diagnosis of cognitive dysfunction in patients with cerebral hemorrhage. Multivariate logistic regression analysis was used to assess the risk factors of cognitive impairment in patients with cerebral hemorrhage.

Results: Cognitive impairment in patients with VD was closely related to the increased levels of SE, NSE, and S100β. There was a strong correlation between MoCA and MMSE scores and the levels of FS, NSE, and S100β. The independent risk factors leading to cognitive impairment in cerebral hemorrhage mainly include family history of cerebrovascular disease, body mass index, hypertension, smoking frequency, and elevated levels of low-density lipoproteins, NSE, FS, and S100β.

Conclusion: NSE, FS, and S100β can be used as important markers for the diagnosis of cognitive impairment in patients with cerebral hemorrhage.

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脑出血患者血清铁蛋白水平与神经功能相关指标及认知功能障碍的相关性。

目的:探讨脑出血患者血清铁蛋白(FS)水平与神经功能相关指标如神经元特异性烯醇化酶(NSE)、S100β蛋白水平及认知功能障碍的相关性。材料与方法:选取急性非外伤性脑出血患者(VD, n = 128)和健康对照(CON, n = 128)。ELISA法检测FS、NSE、S100β水平。采用蒙特利尔认知评估(MoCA)和简易精神状态检查(MMSE)评估认知功能。采用受试者工作特征(ROC)曲线评价SE、NSE和血清S100β对脑出血患者认知功能障碍诊断的预测能力。采用多因素logistic回归分析评估脑出血患者认知功能障碍的危险因素。结果:VD患者的认知功能障碍与SE、NSE和S100β水平升高密切相关。MoCA和MMSE评分与FS、NSE和S100β水平有很强的相关性。脑出血患者认知功能障碍的独立危险因素主要有脑血管病家族史、体重指数、高血压、吸烟频率、低密度脂蛋白、NSE、FS、S100β水平升高。结论:NSE、FS、S100β可作为脑出血患者认知功能障碍诊断的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.