Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2021-10-01 Epub Date: 2021-06-20 DOI:10.1080/10409238.2021.1925218

Elias A Tannous, Peter M Burgers

{"title":"Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).","authors":"Elias A Tannous, Peter M Burgers","doi":"10.1080/10409238.2021.1925218","DOIUrl":null,"url":null,"abstract":"<p><p>DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability of precursors and improper chromosome alignment. When these problems are not addressed, they may lead to chromosome instability and the accumulation of mutations, and even cell death. Therefore, the cell has developed response mechanisms to keep most of these situations under control. Of the many factors that participate in this DNA damage response, members of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) orchestrate the response landscape. Our understanding of two members of the PIKK family, human ATR (yeast Mec1) and ATM (yeast Tel1), and their associated partner proteins, has shown substantial progress through recent biochemical and structural studies. Emerging structural information of these unique kinases show common features that reveal the mechanism of kinase activity.</p>","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"441-454"},"PeriodicalIF":6.2000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2021.1925218","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Biochemistry and Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/10409238.2021.1925218","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/6/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 6

Abstract

DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability of precursors and improper chromosome alignment. When these problems are not addressed, they may lead to chromosome instability and the accumulation of mutations, and even cell death. Therefore, the cell has developed response mechanisms to keep most of these situations under control. Of the many factors that participate in this DNA damage response, members of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) orchestrate the response landscape. Our understanding of two members of the PIKK family, human ATR (yeast Mec1) and ATM (yeast Tel1), and their associated partner proteins, has shown substantial progress through recent biochemical and structural studies. Emerging structural information of these unique kinases show common features that reveal the mechanism of kinase activity.

Abstract Image

查看原文本刊更多论文

细胞周期激酶Mec1(ATR)和Tel1(ATM)机制的新见解。

DNA复制是一个高度精确的过程，通常与细胞周期进程保持完美的节奏。然而，细胞不断面临着各种各样的障碍，如DNA复制受阻、前体缺乏可用性和染色体排列不当。如果这些问题得不到解决，它们可能导致染色体不稳定和突变的积累，甚至细胞死亡。因此，细胞已经发展出反应机制来控制这些情况。在参与这种DNA损伤反应的许多因素中，磷脂酰肌醇3-激酶相关蛋白激酶(PIKKs)家族的成员协调了反应景观。通过最近的生化和结构研究，我们对PIKK家族的两个成员，人类ATR(酵母Mec1)和ATM(酵母Tel1)及其相关伴侣蛋白的了解取得了实质性进展。这些独特的激酶的结构信息显示了揭示激酶活性机制的共同特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Critical Reviews in Biochemistry and Molecular Biology 生物-生化与分子生物学

CiteScore

14.90

自引率

0.00%

发文量

期刊介绍： As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.