The Association Between Male Infertility and Cardiometabolic Disturbances: A Population-Based Study.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2021-04-13 eCollection Date: 2021-04-01 DOI:10.5812/ijem.107418

Samira Behboudi-Gandevani, Razieh Bidhendi Yarandi, Marzieh Rostami Dovom, Fereidoun Azizi, Fahimeh Ramezani Tehrani

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引用次数: 7

Abstract

Background: Further studies are needed to extend our knowledge about the association between male infertility and cardio-metabolic disorders.

Objectives: We aimed to assess the association between male infertility and cardiometabolic disturbances using a population-based design.

Methods: In total, 1611 participants of the Tehran-Lipid and Glucose-Study (phase III) were categorized into two groups of men with documented male infertility (n = 88) and those with at least one live birth and no history of primary infertility (n = 1523). Logistic regression was applied to explore the association between male infertility and cardiometabolic disturbances, including diabetes mellitus, pre-diabetes, hypertension, metabolic syndrome, dyslipidemia, obesity, central obesity, and chronic kidney disease, following adjustment for age and body mass index (BMI).

Results: The unadjusted model revealed a significant association between infertility and hypertension and CKD (OR = 1.8; 95% CI: 1.2, 2.9, P-value = 0.006 and OR = 1.9; 95% CI: 1.1, 3.6, P-value = 0.033), respectively. However, after adjusting for age and BMI, as potential confounders, this association was not significant. Moreover, there was no association between infertility and other cardiometabolic disturbances, including diabetes and pre-diabetes, metabolic syndrome, dyslipidemia, obesity, and central obesity in both unadjusted and adjusted models.

Conclusions: Our study revealed no association between male infertility and cardiometabolic disturbances. The findings can pave the way for further studies to extend our knowledge in this field. More population-based studies with a large sample size are warranted to confirm these findings.

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男性不育与心脏代谢紊乱之间的关系:一项基于人群的研究。

背景:需要进一步的研究来扩大我们对男性不育与心脏代谢紊乱之间关系的认识。目的:我们旨在通过基于人群的设计评估男性不育与心脏代谢紊乱之间的关系。方法:1611名德黑兰血脂和血糖研究(III期)的参与者被分为两组，一组有男性不育症(n = 88)，另一组至少有一次活产且无原发性不育症史(n = 1523)。在调整年龄和体重指数(BMI)后，应用Logistic回归探讨男性不育与心脏代谢紊乱(包括糖尿病、糖尿病前期、高血压、代谢综合征、血脂异常、肥胖、中枢性肥胖和慢性肾脏疾病)之间的关系。结果:未经调整的模型显示不孕症与高血压和CKD之间存在显著相关性(OR = 1.8;95% CI: 1.2, 2.9, p值= 0.006,OR = 1.9;95% CI: 1.1, 3.6, p值= 0.033)。然而，在调整了年龄和BMI(作为潜在的混杂因素)后，这种关联并不显著。此外，在未调整和调整的模型中，不孕症与其他心脏代谢紊乱(包括糖尿病和糖尿病前期、代谢综合征、血脂异常、肥胖和中心性肥胖)之间没有关联。结论:我们的研究显示男性不育和心脏代谢紊乱之间没有关联。这些发现可以为进一步的研究铺平道路，以扩展我们在这一领域的知识。需要更多基于人群的大样本量研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.