First Admission Neutrophil-Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL
Murat Alpua, Bahar Say, Ilknur Yardimci, Ufuk Ergün, Ucler Kisa, Ozlem Doğan Ceylan
{"title":"First Admission Neutrophil-Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke.","authors":"Murat Alpua,&nbsp;Bahar Say,&nbsp;Ilknur Yardimci,&nbsp;Ufuk Ergün,&nbsp;Ucler Kisa,&nbsp;Ozlem Doğan Ceylan","doi":"10.5041/RMMJ.10440","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Our study aimed to determine the relationship between serum periostin levels, and the neutrophil-lymphocyte ratio (NLR) with ischemic stroke subtypes, clinical stroke scales, and acute prognosis in patients with acute ischemic stroke.</p><p><strong>Materials and methods: </strong>Forty-two ischemic stroke patients and 39 age- and sex-matched healthy volunteers were included in our study. Demographic characteristics including age and gender were recorded. Blood serum periostin and NLR values were evaluated in the first 24 hours after admission. Serum periostin levels were compared with healthy controls of similar age and sex. Lesion localization was determined by cranial CT or diffusion MRI of the patients. Stroke scales were recorded on days 1 and 7 of hospitalization in the study group.</p><p><strong>Results: </strong>The mean serum periostin levels were higher than in the control group, but no statistically significant difference was found. There was no correlation between serum periostin levels and prognosis of stroke. First admission NLRs were statistically higher than in the control group. The first admission NLRs were positively correlated with the first admission National Institute of Health Stroke Scale score and the day 7 modified Rankin score.</p><p><strong>Conclusion: </strong>Our study is the first study to evaluate both NLR and serum periostin levels in all types of acute ischemic stroke. While our study did not show that first admission serum periostin levels can be used as a biomarker in ischemic stroke, it did indicate that the first admission NLR can be used for acute prognosis of ischemic stroke.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"12 3","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284988/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rambam Maimonides Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5041/RMMJ.10440","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 2

Abstract

Objectives: Our study aimed to determine the relationship between serum periostin levels, and the neutrophil-lymphocyte ratio (NLR) with ischemic stroke subtypes, clinical stroke scales, and acute prognosis in patients with acute ischemic stroke.

Materials and methods: Forty-two ischemic stroke patients and 39 age- and sex-matched healthy volunteers were included in our study. Demographic characteristics including age and gender were recorded. Blood serum periostin and NLR values were evaluated in the first 24 hours after admission. Serum periostin levels were compared with healthy controls of similar age and sex. Lesion localization was determined by cranial CT or diffusion MRI of the patients. Stroke scales were recorded on days 1 and 7 of hospitalization in the study group.

Results: The mean serum periostin levels were higher than in the control group, but no statistically significant difference was found. There was no correlation between serum periostin levels and prognosis of stroke. First admission NLRs were statistically higher than in the control group. The first admission NLRs were positively correlated with the first admission National Institute of Health Stroke Scale score and the day 7 modified Rankin score.

Conclusion: Our study is the first study to evaluate both NLR and serum periostin levels in all types of acute ischemic stroke. While our study did not show that first admission serum periostin levels can be used as a biomarker in ischemic stroke, it did indicate that the first admission NLR can be used for acute prognosis of ischemic stroke.

Abstract Image

Abstract Image

初次入院中性粒细胞与淋巴细胞比值可能预示缺血性脑卒中的急性预后。
目的:本研究旨在探讨急性缺血性脑卒中患者血清骨膜蛋白水平、中性粒细胞淋巴细胞比(NLR)与缺血性脑卒中亚型、临床脑卒中规模及急性预后的关系。材料与方法:选取42例缺血性脑卒中患者和39例年龄、性别匹配的健康志愿者为研究对象。记录人口统计学特征,包括年龄和性别。入院后24小时测定血清骨膜素和NLR值。比较年龄、性别相近的健康对照者血清骨膜素水平。病变定位由患者头颅CT或弥散性MRI确定。在研究组住院第1天和第7天记录卒中量表。结果:两组患者血清骨膜素水平均高于对照组,但差异无统计学意义。血清骨膜素水平与脑卒中预后无相关性。首次入院nlr显著高于对照组。首次入院nlr与首次入院美国国立卫生研究院卒中量表评分和第7天修正Rankin评分呈正相关。结论:我们的研究是第一个评估所有类型急性缺血性脑卒中患者NLR和血清骨膜蛋白水平的研究。虽然我们的研究没有显示首次入院血清骨膜蛋白水平可以作为缺血性卒中的生物标志物,但它确实表明首次入院NLR可以用于缺血性卒中的急性预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信