Toxicity assessment of dimethyl carbonate following 28 days repeated inhalation exposure.

Environmental analysis, health and toxicology Pub Date : 2021-06-01 Epub Date: 2021-06-16 DOI:10.5620/eaht.2021012
Dongseok Seo
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引用次数: 1

Abstract

Dimethyl carbonate (DMC) has been used as a reagent in methylation reactions, can be used as paints, coatings, and adhesives, and is a chemical that is being used increasing, which poses a health hazard to workers who handle it. So, the toxic reactions of F344 rats with inhalation exposure to 600, 1600, and 5000 ppm concentrations for 6 hours, 5 days a week, 4 weeks was evaluated. During the exposure period, general signs were observed, body weight and food consumption were measured, and hematologic and blood biochemical tests, organ weight measurements, necropsy, and histopathological examination were performed after the end of exposure. During the exposure period, dimethyl carbonate was exposed to an average of 599.26±31.40, 1614.64±80.79 and 5106.83±297.13 ppm in the chambers of the T1, T2 and T3 test groups, respectively. During the test period, general signs, weight change, food consumption, organ weight measurement, necropsy, and histopathological examination did not show any effects related to exposure to the test substance. However, as a result of blood and blood biochemical tests, an increase in AST, ALP, APTT, and PT levels was observed. From these results, it is judged that liver is the target organ when repeated inhalation exposure of dimethyl carbonate, the test substance, for 4 weeks, and the exposure-related effects of the test substance were observed at PT and ALP levels up to 600 ppm exposure concentration, but NOEC (No Observed Effect Concentration) was determined to be less than 600 ppm because it was not judged as an adverse effect.

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重复吸入28天后碳酸二甲酯的毒性评估。
碳酸二甲酯(DMC)已被用作甲基化反应的试剂,可用作油漆、涂料和粘合剂,而且是一种使用越来越多的化学品,对接触它的工人构成健康危害。因此,我们评估了F344大鼠吸入600、1600和5000 ppm浓度6小时,每周5天,4周的毒性反应。暴露期间观察一般体征,测量体重和食量,暴露结束后进行血液学和血液生化检查、器官重量测量、尸检和组织病理学检查。在暴露期间,T1、T2和T3试验组的试验室内碳酸二甲酯的平均暴露量分别为599.26±31.40、1614.64±80.79和5106.83±297.13 ppm。在试验期间,一般体征、体重变化、食物消耗、器官重量测量、尸检和组织病理学检查均未显示与暴露于试验物质有关的任何影响。然而,作为血液和血液生化测试的结果,观察到AST, ALP, APTT和PT水平升高。从这些结果可以判断,当试验物质碳酸二甲酯连续4周反复吸入暴露时,肝脏是靶器官,并且在高达600ppm暴露浓度的PT和ALP水平下观察到试验物质的暴露相关效应,但NOEC(未观察到的效应浓度)被确定为小于600ppm,因为它不被判断为不良效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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