Bacteriophage ICP1: A Persistent Predator of Vibrio cholerae.

IF 8.1 1区 医学 Q1 VIROLOGY
Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-07-27 DOI:10.1146/annurev-virology-091919-072020
Caroline M Boyd, Angus Angermeyer, Stephanie G Hays, Zachary K Barth, Kishen M Patel, Kimberley D Seed
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引用次数: 23

Abstract

Bacteriophages or phages-viruses of bacteria-are abundant and considered to be highly diverse. Interestingly, a particular group of lytic Vibrio cholerae-specific phages (vibriophages) of the International Centre for Diarrheal Disease Research, Bangladesh cholera phage 1 (ICP1) lineage show high levels of genome conservation over large spans of time and geography, despite a constant coevolutionary arms race with their host. From a collection of 67 sequenced ICP1 isolates, mostly from clinical samples, we find these phages have mosaic genomes consisting of large, conserved modules disrupted by variable sequences that likely evolve mostly through mobile endonuclease-mediated recombination during coinfection. Several variable regions have been associated with adaptations against antiphage elements in V. cholerae; notably, this includes ICP1's CRISPR-Cas system. The ongoing association of ICP1 and V. cholerae in cholera-endemic regions makes this system a rich source for discovery of novel defense and counterdefense strategies in bacteria-phage conflicts in nature.

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噬菌体ICP1:霍乱弧菌的持久捕食者。
噬菌体或噬菌体——细菌的病毒——数量丰富,被认为是高度多样化的。有趣的是,国际腹泻病研究中心孟加拉国霍乱噬菌体1 (ICP1)谱系的一组特定的溶血性霍乱弧菌噬菌体(噬菌体)在很长的时间和地理范围内显示出高水平的基因组保护,尽管它们与宿主进行了持续的共同进化军备竞赛。从67个已测序的ICP1分离株(主要来自临床样本)中,我们发现这些噬菌体具有马赛克基因组,由大型保守模块组成,这些模块被可变序列破坏,这些序列可能主要通过共同感染期间移动核内酶介导的重组进化。几个可变区域与霍乱弧菌抗噬菌体元素的适应性有关;值得注意的是,这包括ICP1的CRISPR-Cas系统。在霍乱流行地区,ICP1与霍乱弧菌的持续关联使该系统成为发现自然界细菌-噬菌体冲突中新的防御和反防御策略的丰富来源。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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