Placebo effect in pharmacological management of fibromyalgia: a meta-analysis.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2021-09-10 DOI:10.1093/bmb/ldab015

Filippo Migliorini, Nicola Maffulli, Jörg Eschweiler, Marcel Betsch, Markus Tingart, Giorgia Colarossi

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引用次数: 6

Abstract

Introduction: The management of fibromyalgia involves a combination of pharmacological and non-pharmacological treatments.

Source of data: Recently published literature in PubMed, Google Scholar and Embase databases.

Areas of agreement: Several pharmacological and non-pharmacological strategies have been proposed for the management of fibromyalgia. However, the management of fibromyalgia remains controversial. The administration of placebo has proved to be more effective than no treatment in many clinical settings and evidence supports the 'therapeutic' effects of placebo on a wide range of symptoms.

Areas of controversy: The placebo effect is believed to impact the clinical outcomes, but its actual magnitude is controversial.

Growing points: A meta-analysis comparing pharmacological management versus placebo administration for fibromyalgia was conducted.

Areas timely for developing research: Drug treatment resulted to be more effective than placebo administration for the management of fibromyalgia. Nevertheless, placebo showed a beneficial effect in patients with fibromyalgia. Treatment-related adverse events occurred more frequently in the drug treatment.

Level of evidence: I, Bayesian network meta-analysis of double-blind randomized clinical trials.

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纤维肌痛药理学治疗中的安慰剂效应:一项荟萃分析。

简介:纤维肌痛的治疗包括药物和非药物治疗的结合。数据来源:PubMed、Google Scholar和Embase数据库中最近发表的文献。共识领域:已经提出了几种治疗纤维肌痛的药理学和非药理学策略。然而，纤维肌痛的治疗仍然存在争议。在许多临床环境中，服用安慰剂已被证明比不治疗更有效，证据支持安慰剂对多种症状的“治疗”效果。争议领域:安慰剂效应被认为会影响临床结果，但其实际影响程度存在争议。生长点:一项荟萃分析比较了纤维肌痛的药物管理和安慰剂管理。及时开展研究的领域:治疗纤维肌痛的药物治疗结果比安慰剂治疗更有效。然而，安慰剂在纤维肌痛患者中显示出有益的效果。治疗相关不良事件在药物治疗中发生率更高。证据水平:I，双盲随机临床试验的贝叶斯网络meta分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.