How to use thionamide anti-thyroid drug in the young- what's new?

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Tim Cheetham
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引用次数: 4

Abstract

The excess thyroid hormone secretion that characterises Graves' disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.This underlying mechanism cannot easily be abolished and the mainstay of Graves' disease (GD) management in the young remains thionamide anti-thyroid drug (ATD). Unfortunately, GD will usually recur after a 2 or 3 year course of ATD, even when the stimulatory antibody titres have fallen. The diagnosis of GD therefore usually signals the start of a lengthy period of out-patient assessments and associated venepuncture. Careful, more protracted administration of ATD may increase the likelihood of longer-term remission and reduce the likelihood of the patient developing ATD side-effects. An understanding of how best to use ATD and an awareness of the less well-known consequences of GD and its' treatment - such as excessive weight-gain and long-term hypothyroidism - are also of fundamental importance.Recent clinical studies have shed light on how best to manage the young patient with GD and the associated new information will help to answer some of the questions posed by the young person and their family at diagnosis. This new knowledge is the focus of this article about ATD therapy in the young.

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如何在年轻人中使用硫胺抗甲状腺药物-有什么新进展?
当刺激抗体与甲状腺滤泡细胞上的促甲状腺激素受体结合时,就会产生甲状腺激素分泌过多,这是Graves病(GD)的特征。这种潜在的机制不容易被废除,年轻人格雷夫斯病(GD)治疗的主要方法仍然是硫胺抗甲状腺药物(ATD)。不幸的是,GD通常会在ATD病程2或3年后复发,即使刺激性抗体滴度已经下降。因此,GD的诊断通常标志着长期门诊评估和相关静脉穿刺的开始。谨慎、更持久的ATD给药可能会增加长期缓解的可能性,并降低患者发生ATD副作用的可能性。了解如何最好地利用ATD,并意识到GD及其治疗不太为人所知的后果——如体重过度增加和长期甲状腺功能减退——也至关重要。最近的临床研究揭示了如何最好地管理年轻的GD患者,相关的新信息将有助于回答年轻人及其家人在诊断时提出的一些问题。这篇关于青少年ATD治疗的文章的重点就是这些新知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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