Ultrasonography to detect cardiovascular damage in children with essential hypertension.

IF 1.9 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Ultrasound Pub Date : 2021-07-21 DOI:10.1186/s12947-021-00257-y

Wei Liu, Cui Hou, Miao Hou, Qiu-Qin Xu, Hui Wang, Pei-Pei Gu, Ling Sun, Hai-Tao Lv, Yue-Yue Ding

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引用次数: 5

Abstract

Background: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography.

Methods: All patients with essential hypertension admitted from March 2020 to May 2021 were classified into simple hypertension (group 1, n = 34) and hypertension co-existing with obesity (group 2, n = 11) isolation. Meanwhile 32 healthy children were detected as control heathly group (group 3). We used pulse-wave Doppler to measure carotid-femoral pulse wave velocity (cfPWV), intimal-medial thickness (cIMT) and distensibility of carotid artery (CD). Cardiac structure and function (left atrial diameter [LAD], left ventricular mass [LVM], LVM index [LVMI], relative wall thicknes [RWT], end-diastolic left ventricular internal diameter [LVIDd], diastolic interventricular septum thickness [IVSd], diastolic left ventricular posterior wall thickness [LVPWd], root diameter of aorta [AO], E peak, A peak, E' peak, A' peak, E/E' ratio, and E/A ratio) were measured by echocardiography.

Results: The cfPWV of children in group 1 and group 2 were significantly higher than healthy children in group 3. Significant differences were observed in LVM, LVMI, RWT, LVIDd, IVSd, LVPWd, LAD, A peak, E' peak, A' peak, and E/E' among three groups.

Conclusion: Children and adolescents with essential hypertension demonstrate target organ damages in the heart and blood vessels.

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超声检查儿童原发性高血压的心血管损害。

背景:成人原发性高血压可能始于儿童期。原发性高血压患儿对心脏和血管的损害是隐性的，难以发现。我们采用无创超声检查早期高血压患儿心血管结构和功能的变化。方法:将2020年3月~ 2021年5月收治的原发性高血压患者分为单纯性高血压(1组，n = 34)和高血压合并肥胖(2组，n = 11)两组。同时取32例健康儿童作为对照组(第三组)，采用脉冲波多普勒测量颈动脉-股动脉脉波速度(cfPWV)、颈动脉内膜-内侧厚度(cIMT)和颈动脉扩张性(CD)。超声心动图测量心脏结构和功能(左房内径[LAD]、左室质量[LVM]、左室质量指数[LVMI]、相对壁厚[RWT]、舒张末期左室内径[LVIDd]、舒张期室间隔厚度[IVSd]、舒张期左室后壁厚度[LVPWd]、主动脉根径[AO]、E峰、A峰、E′峰、E/E′比、E/A比)。结果:1、2组儿童cfPWV显著高于3组健康儿童。三组患者LVM、LVMI、RWT、LVIDd、IVSd、LVPWd、LAD、A峰、E′峰、A′峰、E/E′差异均有统计学意义。结论:儿童和青少年原发性高血压表现为心脏和血管靶器官损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Ultrasound CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cardiovascular Ultrasound is an online journal, publishing peer-reviewed: original research; authoritative reviews; case reports on challenging and/or unusual diagnostic aspects; and expert opinions on new techniques and technologies. We are particularly interested in articles that include relevant images or video files, which provide an additional dimension to published articles and enhance understanding. As an open access journal, Cardiovascular Ultrasound ensures high visibility for authors in addition to providing an up-to-date and freely available resource for the community. The journal welcomes discussion, and provides a forum for publishing opinion and debate ranging from biology to engineering to clinical echocardiography, with both speed and versatility.