Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2021-01-01 Epub Date: 2021-02-20 DOI:10.12938/bmfh.2020-063

Kentaro Tominaga, Atsunori Tsuchiya, Oki Nakano, Yasutoshi Kuroki, Kentaro Oka, Ayaka Minemura, Asami Matsumoto, Motomichi Takahashi, Yoshihiro Kadota, Takumi Tochio, Yusuke Niwa, Tomoaki Yoshida, Masatoshi Sato, Takeshi Yokoo, Satoru Hashimoto, Junji Yokoyama, Jun Matsuzawa, Katsuya Fujimori, Shuji Terai

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引用次数: 7

Abstract

Sarcopenia causes functional disorders and decreases the quality of life. Thus, it has attracted substantial attention in the aging modern world. Dysbiosis of the intestinal microbiota is associated with sarcopenia; however, it remains unclear whether prebiotics change the microbiota composition and result in the subsequent recovery of muscle atrophy in elderly patients with sarcopenia. This study aimed to assess the effects of prebiotics in super-elderly patients with sarcopenia. We analyzed the effects of 1-kestose on the changes in the intestinal microbiota and body composition using a next-generation sequencer and a multi-frequency bioimpedance analysis device. The Bifidobacterium longum population was significantly increased in the intestine after 1-kestose administration. In addition, in all six patients after 12 weeks of 1-kestose administration, the skeletal muscle mass index was greater, and the body fat percentage was lower. This is the first study to show that administration of a prebiotic increased the population of B. longum in the intestinal microbiota and caused recovery of muscle atrophy in super-elderly patients with sarcopenia.

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1-酮糖在老年肌肉减少症患者中的益生元作用与肌肉质量的增加有关。

肌肉减少症会导致功能障碍，降低生活质量。因此，它在老龄化的现代世界中引起了极大的关注。肠道菌群失调与肌肉减少症有关;然而，益生元是否改变微生物群组成并导致老年肌肉减少症患者随后肌肉萎缩的恢复尚不清楚。本研究旨在评估益生元对老年肌肉减少症患者的影响。我们使用新一代测序仪和多频生物阻抗分析设备分析了1-酮糖对肠道微生物群和身体组成变化的影响。1-酮糖处理后，肠内长双歧杆菌数量显著增加。此外，所有6例患者在1-酮糖给药12周后，骨骼肌质量指数更高，体脂率更低。这是第一个研究表明，服用益生元可以增加肠道微生物群中的长芽胞杆菌数量，并导致患有肌肉减少症的超高龄患者肌肉萎缩的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.