A Review of miR-326 and Female Related Diseases.

IF 1.6 4区生物学 Q4 CELL BIOLOGY

Acta Histochemica Et Cytochemica Pub Date : 2021-06-29 Epub Date: 2021-04-22 DOI:10.1267/ahc.20-00027

Li-Na Lin, Qing-Mei Zhang, Ying-Ying Ge, Bin Luo, Xiao-Xun Xie

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引用次数: 6

Abstract

MicroRNA (miRNA), a non-coding single-stranded RNA molecule with 20-23 nucleotides encoded by endogenous genes, plays an essential role in maintaining normal cell function and regulating cell proliferation, differentiation, apoptosis, autophagy, and cell metabolism. The imbalance between miRNA and genes can cause a series of diseases, including malignancies. miRNA-326 (miR-326) is extensively known for its core regulation of various biological processes. This review presents an overview of the highlights of miR-326 in female-related diseases. To understand the impact of miR-326 on female disorders, we search all published studies about miR-326 having a high incidence in female conditions, including cervical cancer, endometrial cancer, breast cancer, intrauterine adhesion, and multiple autoimmune diseases. We aim to learn about the mutual regulation mechanism between miR-326 and related genes and signaling pathways, as well as to elaborate on the value of miR-326 as a potential biomarker and therapeutic target of female diseases. Our results provide reliable evidence and new strategies for treating female tumors and autoimmune diseases.

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miR-326与女性相关疾病研究进展

MicroRNA (miRNA)是一种由内源性基因编码的20-23个核苷酸的非编码单链RNA分子，在维持细胞正常功能，调控细胞增殖、分化、凋亡、自噬和细胞代谢等方面发挥着重要作用。miRNA和基因之间的不平衡会导致一系列疾病，包括恶性肿瘤。miRNA-326 (miR-326)因其对各种生物过程的核心调控而广为人知。这篇综述综述了miR-326在女性相关疾病中的重点。为了了解miR-326对女性疾病的影响，我们检索了所有已发表的关于miR-326在女性疾病中高发的研究，包括宫颈癌、子宫内膜癌、乳腺癌、宫内粘连和多种自身免疫性疾病。我们旨在了解miR-326与相关基因和信号通路的相互调控机制，阐述miR-326作为女性疾病潜在的生物标志物和治疗靶点的价值。我们的结果为治疗女性肿瘤和自身免疫性疾病提供了可靠的证据和新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Histochemica Et Cytochemica 生物-细胞生物学

CiteScore

3.50

自引率

8.30%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Histochemica et Cytochemica is the official online journal of the Japan Society of Histochemistry and Cytochemistry. It is intended primarily for rapid publication of concise, original articles in the fields of histochemistry and cytochemistry. Manuscripts oriented towards methodological subjects that contain significant technical advances in these fields are also welcome. Manuscripts in English are accepted from investigators in any country, whether or not they are members of the Japan Society of Histochemistry and Cytochemistry. Manuscripts should be original work that has not been previously published and is not being considered for publication elsewhere, with the exception of abstracts. Manuscripts with essentially the same content as a paper that has been published or accepted, or is under consideration for publication, will not be considered. All submitted papers will be peer-reviewed by at least two referees selected by an appropriate Associate Editor. Acceptance is based on scientific significance, originality, and clarity. When required, a revised manuscript should be submitted within 3 months, otherwise it will be considered to be a new submission. The Editor-in-Chief will make all final decisions regarding acceptance.