Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study

Q2 Medicine

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2021-11-01 DOI:10.1016/j.nbscr.2021.100069

Jaidaa Mekky, Osama El-Kholy, Eman Hamdy, Akram Fawzy

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引用次数: 1

Abstract

It is well established that certain alteration of sleep disorders occur in patients with wake-up stroke (WUS) such as sleep disordered breathing, periodic limb movements and sleep duration. However, the data are lacking about the microarchitecture of different sleep stages among those patients.

Aim of work

To compare the polysomnographic microarchitecture of rapid eye movement (REM) sleep between WUS and daytime stroke (DTS).

Methods

A cross-sectional polysomnographic study was conducted on 20 patients with WUS and 20 patients with DTS, with analysis of REM sleep microarchitecture in specific.

Results

Patients with WUS had significantly shorter REM stage (11.76 ± 5.48% in WUS versus 16.59 ± 5.33% in DTS, P = 0.008), longer early morning REM was (25.70 ± 13.13 min in WUS versus 4.15 ± 4.69 min in DTS, P=<0.001), higher apnea-hypopnea index (AHI) during REM (6.29 ± 10.18 in WUS versus 1.10 ± 4.57 in DTS, P = 0.009), and lower mean Oxygen saturation during REM (92.70 ± 3.63 WUS versus 95.45 ± 1.35 DTS, P = 0.012). The OR of early morning REM duration was 1.8 (CI 1.099–3.130, p = 0.021) for WUS.

Conclusion

The microarchitecture of REM sleep is disrupted in patients with wake-up stroke.

Abstract Image

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唤醒性缺血性卒中患者的快速眼动睡眠微结构改变:一项多导睡眠图研究

醒脑卒中(WUS)患者存在睡眠障碍的某些改变，如睡眠呼吸障碍、周期性肢体运动和睡眠持续时间。然而，缺乏这些患者不同睡眠阶段的微结构数据。研究目的:比较WUS与日间卒中患者快速眼动(REM)睡眠的多导睡眠图微结构。方法对20例WUS患者和20例DTS患者进行横断面多导睡眠图研究，重点分析REM睡眠微结构。ResultsPatients本人与REM阶段都很短(11.76±5.48%,本人在DTS和16.59±5.33%,P = 0.008),再清晨REM是(25.70±13.13分钟在DTS吴苹和4.15±4.69分钟,P = & lt; 0.001),高于低通气指数(AHI)在REM(6.29±10.18在DTS吴苹和1.10±4.57,P = 0.009),和更低的平均血氧饱和度在REM(本人92.70±3.63和95.45±1.35 DTS, P = 0.012)。WUS的晨间REM持续时间OR为1.8 (CI 1.099 ~ 3.130, p = 0.021)。结论觉醒性脑卒中患者快速眼动睡眠的微结构被打乱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Sleep and Circadian Rhythms Neuroscience-Behavioral Neuroscience

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Neurobiology of Sleep and Circadian Rhythms is a multidisciplinary journal for the publication of original research and review articles on basic and translational research into sleep and circadian rhythms. The journal focuses on topics covering the mechanisms of sleep/wake and circadian regulation from molecular to systems level, and on the functional consequences of sleep and circadian disruption. A key aim of the journal is the translation of basic research findings to understand and treat sleep and circadian disorders. Topics include, but are not limited to: Basic and translational research, Molecular mechanisms, Genetics and epigenetics, Inflammation and immunology, Memory and learning, Neurological and neurodegenerative diseases, Neuropsychopharmacology and neuroendocrinology, Behavioral sleep and circadian disorders, Shiftwork, Social jetlag.