Prevalence and diagnostic values of laboratory animal allergy among research personnel.

IF 2.3 4区医学 Q3 ALLERGY

Asian Pacific journal of allergy and immunology Pub Date : 2025-03-01 DOI:10.12932/AP-220321-1094

Sung-Yoon Kang, Ha-Kyeong Won, So-Young Park, Shuaixia Yu, Sang Min Lee, Sang Pyo Lee

{"title":"Prevalence and diagnostic values of laboratory animal allergy among research personnel.","authors":"Sung-Yoon Kang, Ha-Kyeong Won, So-Young Park, Shuaixia Yu, Sang Min Lee, Sang Pyo Lee","doi":"10.12932/AP-220321-1094","DOIUrl":null,"url":null,"abstract":"Background: Laboratory animal allergy (LAA) has not been sufficiently investigated, although LAA is a relatively common work-related condition and important occupational hazard.Objective: This study aimed to evaluate the prevalence of LAA and analyze the diagnostic value of serum specific IgE (sIgE) using the skin prick test (SPT) as a comparative standard.Methods: Korean laboratory animal researchers who attended an annual symposium were requested to answer questionnaires regarding demographic characteristics, laboratory animal exposure, and symptoms related to laboratory animal exposure. A total of 213 participants underwent a SPT with mouse and rat epithelial allergen extract. We measured sIgE against rodent urine, epithelium, and serum allergens from 63 participants. SPT outcome served as the comparison method.Results: Among 223 participants, 213 had direct/indirect exposure to mice or rats, and 30% and 14% of them complained of allergic symptoms after exposure to mouse and rat, respectively. Sensitization rates were 28% for mouse epithelium and 23% for rat epithelium. Compared to a positive SPT with wheal ≥ 3 mm, presence of sIgE against rodent allergens showed a higher positive predictive value of 87-91% at a cut-off level of 0.35 KUA/L. Agreement between SPT and sIgE test was determined to be fair to moderate.Conclusions: Sensitization and allergy to mouse and rat were prevalent among laboratory personnel in Korea. When evaluating cases of potential LAA, the sIgE test can provide added diagnostic value if the skin test is positive. Careful interpretation of two tests is required to accurately diagnose LAA.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"34-39"},"PeriodicalIF":2.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific journal of allergy and immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12932/AP-220321-1094","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Laboratory animal allergy (LAA) has not been sufficiently investigated, although LAA is a relatively common work-related condition and important occupational hazard.

Objective: This study aimed to evaluate the prevalence of LAA and analyze the diagnostic value of serum specific IgE (sIgE) using the skin prick test (SPT) as a comparative standard.

Methods: Korean laboratory animal researchers who attended an annual symposium were requested to answer questionnaires regarding demographic characteristics, laboratory animal exposure, and symptoms related to laboratory animal exposure. A total of 213 participants underwent a SPT with mouse and rat epithelial allergen extract. We measured sIgE against rodent urine, epithelium, and serum allergens from 63 participants. SPT outcome served as the comparison method.

Results: Among 223 participants, 213 had direct/indirect exposure to mice or rats, and 30% and 14% of them complained of allergic symptoms after exposure to mouse and rat, respectively. Sensitization rates were 28% for mouse epithelium and 23% for rat epithelium. Compared to a positive SPT with wheal ≥ 3 mm, presence of sIgE against rodent allergens showed a higher positive predictive value of 87-91% at a cut-off level of 0.35 KUA/L. Agreement between SPT and sIgE test was determined to be fair to moderate.

Conclusions: Sensitization and allergy to mouse and rat were prevalent among laboratory personnel in Korea. When evaluating cases of potential LAA, the sIgE test can provide added diagnostic value if the skin test is positive. Careful interpretation of two tests is required to accurately diagnose LAA.

查看原文本刊更多论文

研究人员对实验动物过敏的发生率和诊断价值。

背景：尽管实验动物过敏（LAA）是一种相对常见的工作相关疾病和重要的职业危害，但尚未对其进行充分调查：本研究旨在评估 LAA 的患病率，并以皮肤点刺试验（SPT）为比较标准，分析血清特异性 IgE（sIgE）的诊断价值：方法：要求参加年度研讨会的韩国实验动物研究人员回答有关人口统计学特征、实验动物接触情况和实验动物接触相关症状的问卷。共有 213 名与会者接受了小鼠和大鼠上皮过敏原提取物的 SPT 检测。我们测量了 63 名参与者针对啮齿动物尿液、上皮细胞和血清过敏原的 sIgE。结果：结果：在 223 名参与者中，有 213 人直接或间接接触过小鼠或大鼠，其中 30% 和 14% 的人在接触小鼠和大鼠后出现过敏症状。小鼠上皮细胞的致敏率为 28%，大鼠上皮细胞的致敏率为 23%。在 0.35 KUA/L 的临界值下，啮齿类动物过敏原 sIgE 的阳性预测值为 87%-91%，而 SPT 阳性且乳突≥ 3 mm 的阳性预测值为 87%-91%。SPT 和 sIgE 检测之间的一致性被确定为中等偏上：结论：韩国实验室人员对小鼠和大鼠过敏的情况十分普遍。在评估潜在的 LAA 病例时，如果皮试呈阳性，sIgE 试验可提供额外的诊断价值。要准确诊断 LAA，需要对两种检测结果进行仔细解读。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.