Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.

IF 2.3 4区医学 Q3 ALLERGY

Asian Pacific journal of allergy and immunology Pub Date : 2024-12-01 DOI:10.12932/AP-190221-1073

Yasuhiro Masuta, Yoriaki Komeda, Ikue Sekai, Akane Hara, Masayuki Kurimoto, Keisuke Yoshikawa, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Osamu Maenishi, Tomohiro Watanabe, Masatoshi Kudo

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引用次数: 0

Abstract

Background: Granulomatosis with polyangiitis (GPA) is characterized by granulomatous inflammation, vasculitis, and elevated levels of serum proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibody (PR3-ANCA).

Objective: We tried to characterize immune cells accumulated into the lung lesions of a GPA patient exhibiting spontaneous regression.

Methods: Transbronchial lung biopsy (TBLB) samples were subjected to immunohistochemical analyses.

Results: Multiple lung nodules were detected by CT. TBLB showed granulomatous inflammation and small vessel vasculitis. This case was diagnosed as GPA based on pathological findings and elevation of PR-3 ANCA levels. Spontaneous disappearance of multiple lung nodules was observed in CT. CD3+ T cells and CD20+ B cells accumulated in the inflammatory lesions surrounding the vessels whereas granulomatous inflammation was mainly comprised of CD3+ T cells and CD68+ macrophages, but not B cells or myeloperoxidase+ neutrophils.

Conclusions: We characterized immune cell compositions of the lung lesions of a patient with GPA exhibiting spontaneous regression.

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肉芽肿伴多血管炎的免疫组织化学特征表现为自发消退。

背景：肉芽肿伴多血管炎（GPA）以肉芽肿性炎症、血管炎和血清蛋白酶3（PR3）-抗中性粒细胞胞浆抗体（PR3-ANCA）水平升高为特征：目的：我们试图描述一名自发消退的 GPA 患者肺部病变中积累的免疫细胞的特征：方法：对经支气管肺活检（TBLB）样本进行免疫组化分析：结果：CT 发现多个肺结节。TBLB显示肉芽肿性炎症和小血管炎。根据病理结果和 PR-3 ANCA 水平的升高，该病例被诊断为 GPA。CT 观察到多个肺结节自发消失。CD3+ T细胞和CD20+ B细胞聚集在血管周围的炎症病灶中，而肉芽肿炎症主要由CD3+ T细胞和CD68+巨噬细胞组成，但不包括B细胞或髓过氧化物酶+中性粒细胞：我们描述了一名表现为自发性消退的 GPA 患者肺部病变的免疫细胞组成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.