Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2021-12-01 DOI:10.1080/13510002.2021.1952819

Marina Yurievna Maksimova, Alexander Vladimirovich Ivanov, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Fatima Ramazanovna Ochtova, Ekaterina Taymurazovna Suanova, Maria Petrovna Kruglova, Mikhail Aleksanrovich Piradov, Aslan Amirkhanovich Kubatiev

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引用次数: 6

Abstract

Objective: Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in patients with an acute period.

Patients and methods: A total of 177 patients were examined. Total and reduced forms of LMWTs were determined in the first 10-24 h. Stroke severity and functional state were estimated using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRs) at admission and after 21 days.

Results: Patients with high levels of total Hcy (> 19 μM) showed significantly reduced redox statuses of all LMWTs. Patients with low total GSH levels (≤ 1.07 μM) were at an increased risk of higher stroke severity (NIHSS > 10) compared to patients with a total GSH level > 2.64 μM (age/gender-adjusted odds ratio: 4.69, 95% CI: 1.43-15.4).

Discussion: (1) low total GSH level can be considered as a novel risk marker for the severity of acute stroke in conditions of low redox status of LMWTs and (2) high Hcy levels associated with low redox status of LMWTs.

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谷胱甘肽对急性缺血性脑卒中严重程度和预后的影响:氨基硫醇氧化还原状态的可能作用。

目的:急性脑缺血伴随着低分子量氨基硫醇(LMWTs)稳态的破坏，如同型半胱氨酸(Hcy)、半胱氨酸(Cys)和谷胱甘肽(GSH)。我们研究了血浆中lmwt的氧化还原平衡及其对急性期缺血性卒中患者严重程度和功能结局的影响。患者和方法:共检查177例患者。在前10-24小时内测定lmwt的总形态和还原形态。采用美国国立卫生研究院卒中量表(NIHSS)和改进的Rankin量表(mRs)在入院时和21天后对卒中严重程度和功能状态进行评估。结果:高水平总Hcy (> 19 μM)患者的所有lmwt氧化还原状态均显著降低。与总GSH水平> 2.64 μM的患者相比，总GSH水平低(≤1.07 μM)的患者卒中严重程度较高(NIHSS > 10)的风险增加(年龄/性别校正优势比:4.69,95% CI: 1.43-15.4)。讨论:(1)低总谷胱甘肽水平可被视为低低氧化还原状态下急性卒中严重程度的新风险标志;(2)高Hcy水平与低氧化还原状态相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.