Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin/Multidrug-Resistant Tuberculosis Patients.

IF 1.8 Q3 HEALTH CARE SCIENCES & SERVICES

Patient Related Outcome Measures Pub Date : 2021-06-29 eCollection Date: 2021-01-01 DOI:10.2147/PROM.S316337

Zenawi Zeramariam Araia, Araia Berhane Mesfin, Amanuel Hadgu Mebrahtu, Adiam Ghebreyohanns Tewelde, Asmerom Tesfagiorgis Tewelde, Solyana Ngusbrhan Kidane

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引用次数: 0

Abstract

Background: Despite the negative impact of tuberculosis (TB) on patients' quality of life, TB control programs focus on biological and clinical parameters to manage and monitor TB patients. In our setting, patients' perception of their experience with TB and the impacts of TB on patients' physical, mental, and social wellbeing remain unknown.

Objective: The objective of this study was to evaluate the health-related quality of life (HRQOL) among rifampicin/multidrug-resistant TB (RR/MDR-TB) in comparison to drug-susceptible TB (DS-TB) patients in Eritrea.

Methods: A cross-sectional study was conducted in RR/MDR-TB and DS-TB patients under treatment. Anonymized data collected using the WHOQOL-BREF questionnaire were analyzed using SPSS version 23. Frequency, mean and standard deviation were used to describe the data. Mean group score comparison and relationship between variables were assessed using t-test. Domain score was calculated with a mean score of items within each domain and scaled positively, a higher (increasing) score denoting a higher quality of life. Internal consistency was measured using Cronbach's alpha and statistical significance was set at p < 0.05.

Results: A total of 92 patients (46 RR/MDR-TB and 46 DS-TB) participated in the study. Environmental (40.63 ± 10.72) and physical domains (61.80 ±17.18) were the two most affected domains in RR/MDR-TB and DS-TB patients, respectively. The psychological domain was the least affected domain in RR/MDR-TB (48.28 ± 20.83) and DS-TB patients (76.63 ±15.32). RR/MDR-TB patients had statistically lower mean scores in all domains than DS-TB patients.

Conclusion: HRQOL was impaired in both groups, but RR/MDR-TB patients had a worse health-related quality of life.

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厄立特里亚结核病患者与健康相关的生活质量：药物敏感型肺结核患者与利福平/耐多药肺结核患者的比较。

背景：尽管肺结核（TB）对患者的生活质量有负面影响，但肺结核控制项目仍将重点放在管理和监测肺结核患者的生物和临床参数上。在我们的环境中，患者对其结核病经历的感知以及结核病对患者身体、精神和社会福祉的影响仍是未知数：本研究旨在评估厄立特里亚耐利福平/耐多药肺结核（RR/MDR-TB）患者与耐药肺结核（DS-TB）患者的健康相关生活质量（HRQOL）：对正在接受治疗的 RR/MDR-TB 和 DS-TB 患者进行了横断面研究。使用 WHOQOL-BREF 问卷收集的匿名数据使用 SPSS 23 版进行分析。使用频率、平均值和标准差来描述数据。组间平均分比较和变量之间的关系采用 t 检验进行评估。领域得分以每个领域内项目的平均分计算，并按正向标度，得分越高（增加），表示生活质量越高。内部一致性采用 Cronbach's alpha 测量，统计显著性以 p < 0.05 为标准：共有 92 名患者（46 名 RR/MDR-TB，46 名 DS-TB）参与了研究。环境领域（40.63 ± 10.72）和身体领域（61.80 ± 17.18）分别是 RR/MDR-TB 和 DS-TB 患者受影响最大的两个领域。心理领域是 RR/MDR-TB 患者（48.28 ± 20.83）和 DS-TB 患者（76.63 ± 15.32）受影响最小的领域。据统计，RR/MDR-TB 患者在所有领域的平均得分均低于 DS-TB 患者：结论：两组患者的健康相关生活质量都受到了影响，但 RR/MDR-TB 患者的健康相关生活质量更差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Patient Related Outcome Measures HEALTH CARE SCIENCES & SERVICES-

自引率

4.80%

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审稿时长

16 weeks