The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology.

IF 4.7 2区心理学 Q1 BEHAVIORAL SCIENCES

Behavioral and Brain Functions Pub Date : 2021-07-07 DOI:10.1186/s12993-021-00181-1

Vladimir N Nikolenko, Negoriya A Rizaeva, Narasimha M Beeraka, Marine V Oganesyan, Valentina A Kudryashova, Alexandra A Dubovets, Irina D Borminskaya, Kirill V Bulygin, Mikhail Y Sinelnikov, Gjumrakch Aliev

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Abstract

Introduction: The claustrum is a structure involved in formation of several cortical and subcortical neural microcircuits which may be involved in such functions as conscious sensations and rewarding behavior. The claustrum is regarded as a multi-modal information processing network. Pathology of the claustrum is seen in certain neurological disorders. To date, there are not enough comprehensive studies that contain accurate information regarding involvement of the claustrum in development of neurological disorders.

Objective: Our review aims to provide an update on claustrum anatomy, ontogenesis, cytoarchitecture, neural networks and their functional relation to the incidence of neurological diseases.

Materials and methods: A literature review was conducted using the Google Scholar, PubMed, NCBI MedLine, and eLibrary databases.

Results: Despite new methods that have made it possible to study the claustrum at the molecular, genetic and epigenetic levels, its functions and connectivity are still poorly understood. The anatomical location, relatively uniform cytoarchitecture, and vast network of connections suggest a divergent role of the claustrum in integration and processing of input information and formation of coherent perceptions. Several studies have shown changes in the appearance, structure and volume of the claustrum in neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), autism, schizophrenia, and depressive disorders. Taking into account the structure, ontogenesis, and functions of the claustrum, this literature review offers insight into understanding the crucial role of this structure in brain function and behavior.

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神秘的耳廓神经回路及其在神经退行性病理学中作用的最新进展。

导言大脑皮质和皮质下神经微电路可能参与了意识感觉和奖励行为等功能的形成。耳丛被认为是一个多模式信息处理网络。在某些神经系统疾病中，可以看到鼓室出现病变。迄今为止，还没有足够全面的研究能准确说明神经系统疾病的发生与神经丛膜的参与有关：我们的综述旨在提供有关鼓室解剖、本体发育、细胞结构、神经网络及其与神经系统疾病发病率的功能关系的最新信息：使用 Google Scholar、PubMed、NCBI MedLine 和 eLibrary 数据库进行文献综述：结果：尽管新方法使人们有可能从分子、遗传和表观遗传学的层面研究鼓室，但人们对其功能和连接性仍然知之甚少。解剖学上的位置、相对统一的细胞结构和庞大的连接网络表明，鼓室在整合和处理输入信息以及形成连贯的知觉方面扮演着不同的角色。多项研究表明，在帕金森病（PD）、阿尔茨海默病（AD）、自闭症、精神分裂症和抑郁症等神经退行性疾病中，鼓室的外观、结构和体积都发生了变化。考虑到鼓室的结构、本体发生和功能，这篇文献综述为了解鼓室在大脑功能和行为中的关键作用提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioral and Brain Functions 医学-行为科学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.