Simple Preparation of Carbon Dots and Application in Cephalosporin Detection.

Yan Li, He-Ping Yang, Shu Chen, Xiang-Jiang Wu, Yun-Fei Long
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引用次数: 3

Abstract

Carbon dots have good biocompatibility, low toxicity, excellent photoluminescence properties, and good light stability, endowing them good application prospects in drug detection, chemical analysis, drug delivery, and other fields. In this study, p-phenylenediamine was used as the carbon source, and carbon dots were synthesized in hydrochloric acid medium using microwave method. When the excitation wavelength is about 300 nm, a strong emission peak of 689 nm is detected for the synthesized carbon dots. Carbon dots' size is about 4.0±0.2 nm, and the carbon dots with spherical shape are uniformly distributed. The quantum yield of carbon dots is 8.07%. In addition, cephalosporins. were detected and analyzed using synthetic carbon dots. The results show that the presence of cephalosporins reduced the fluorescence intensity of carbon dots, and the reduced fluorescence intensity of the synthesized carbon dots showed a linear correlation with the cephalosporins' concentration. Cephalosporins' detection scope is 0.2 μmol/L to 80 μ mol/L, and the detection limit is 0.084 μ mol/L. A mechanism study shows that the effect of cephalosporins on carbon dot's fluorescence intensity can be attributed to the inner filter effect of cephalosporins. On this basis, a sensitive and 0selective cephalosporins detection method was established. Furthermore, this established method for cephalosporins detection was applied to real samples, resulting in a low relative standard deviation (RSD) and good recoveries.

碳点的简易制备及其在头孢菌素检测中的应用。
碳点具有良好的生物相容性、低毒性、优异的光致发光性能和良好的光稳定性,在药物检测、化学分析、给药等领域具有良好的应用前景。本研究以对苯二胺为碳源,在盐酸介质中采用微波法制备碳点。当激发波长约为300 nm时,合成的碳点有689 nm的强发射峰。碳点尺寸约为4.0±0.2 nm,碳点呈球形,分布均匀。碳点的量子产率为8.07%。此外,还有头孢菌素。用合成碳点进行检测和分析。结果表明,头孢菌素的存在降低了碳点的荧光强度,合成的碳点荧光强度的降低与头孢菌素的浓度呈线性相关。头孢菌素的检测范围为0.2 μmol/L ~ 80 μmol/L,检出限为0.084 μmol/L。机理研究表明,头孢菌素对碳点荧光强度的影响可归因于头孢菌素的内过滤作用。在此基础上,建立了一种灵敏、无选择性的头孢菌素检测方法。建立的头孢菌素检测方法适用于实际样品,相对标准偏差(RSD)低,回收率好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of nanoscience and nanotechnology
Journal of nanoscience and nanotechnology 工程技术-材料科学:综合
自引率
0.00%
发文量
0
审稿时长
3.6 months
期刊介绍: JNN is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. JNN publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, theory and computation, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology.
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