The Release of Indium Ion Derived from Epithelial Cells and Macrophages Solubilization Contribute to Pneumotoxicity Induced by Indium Oxide Nanoparticles.

Mei Wang, Wei Song, Zhaofang Chen, Huilin Li, Jinhua Yuan, Hao Wang, Liya Wang, Jing Cao, Yue You, Linlin Chen, Feng Zhao, Yunhui Li
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引用次数: 1

Abstract

Occupational exposure to indium oxide and indium containing particles has been associated with the development of severe lung diseases called "indium lung." According to the survey of occupational hygiene, indium oxide nanoparticles have been identified in the workplaces and the lungs of workers. To date, the potential mechanism of the pneumotoxicity has been poorly understood and no effective therapies are available against "indium lung." Our present study reported that the exposure of indium oxide nanoparticles damaged lung epithelial cells and alveolar macrophages and induced pulmonary alveolar proteinosis and inflammation in rats. In the 8-week post-exposure period, the indium oxide nanoparticles still mostly accumulated in the lungs and then persistently release indium ions in two months after exposure. In vitro, the epithelial cells show the greater potential for release of indium ions from indium oxide nanoparticles compared with the macrophages. EDTA-2Na, a metal chelating agent expected to remove the indium ions, was found to significantly reduced the cytotoxicity of indium oxide nanoparticles. Herein, the pneumotoxicity may be attributed to the slow and incremental release of indium ions from indium oxide nanoparticles primary dissolved by epithelial cells and macrophages, at least partially. The study may provide some insights to the pathogenicity mechanisms of "indium lung" and some clues against the health hazards of occupational inhaled indium oxide nanoparticles at the workplaces.

来自上皮细胞的铟离子的释放和巨噬细胞的增溶有助于氧化铟纳米颗粒诱导的肺毒性。
职业接触氧化铟和含铟颗粒与被称为“铟肺”的严重肺部疾病的发展有关。根据职业卫生调查,已在工作场所和工人肺部发现氧化铟纳米颗粒。迄今为止,肺毒性的潜在机制尚不清楚,也没有针对“铟肺”的有效治疗方法。我们的研究报告了氧化铟纳米颗粒暴露在大鼠肺上皮细胞和肺泡巨噬细胞中,并诱导肺泡蛋白沉积和炎症。在暴露后8周内,氧化铟纳米颗粒仍主要积聚在肺部,并在暴露后2个月内持续释放铟离子。在体外实验中,与巨噬细胞相比,上皮细胞表现出更大的氧化铟纳米颗粒释放铟离子的潜力。EDTA-2Na是一种有望去除铟离子的金属螯合剂,可以显著降低氧化铟纳米颗粒的细胞毒性。在这里,肺毒性可能归因于至少部分地被上皮细胞和巨噬细胞溶解的氧化铟纳米颗粒缓慢和增量释放铟离子。本研究为“铟肺”的发病机制提供了新的认识,为工作场所职业性吸入氧化铟纳米粒子的健康危害提供了线索。
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来源期刊
Journal of nanoscience and nanotechnology
Journal of nanoscience and nanotechnology 工程技术-材料科学:综合
自引率
0.00%
发文量
0
审稿时长
3.6 months
期刊介绍: JNN is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. JNN publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, theory and computation, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology.
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