Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-12-01 DOI:10.1080/19932820.2021.1949798

Mohamad Nidal Khabaz, Imtiaz Ahmad Qureshi, Jaudah Ahmad Al-Maghrabi

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引用次数: 1

Abstract

This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies.A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays.Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03).These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma.

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瘦素的表达与膀胱癌的预后密切相关。

本研究探讨了膀胱癌病例中瘦素的表达及其在膀胱恶性肿瘤中的诊断和预后价值。采用免疫组化方法对128例膀胱癌患者和24例正常膀胱进行了瘦素表达的组织芯片检测。在转化过程中，瘦素表达上调，在123例(96%)膀胱肿瘤的恶性尿路上皮中被鉴定为棕色细胞质颗粒，其中68例(53.1%)呈高(中至强)染色。强染色与高分期(P = 0.001)、固有肌层浸润(P = 0.001)相关

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.