The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2021-10-01 DOI:10.4103/2045-9912.318858

Yoshinori Tanaka, Masataka Kiuchi, Yasuki Higashimura, Yuji Naito, Katsuhiro Koyama

{"title":"The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial.","authors":"Yoshinori Tanaka, Masataka Kiuchi, Yasuki Higashimura, Yuji Naito, Katsuhiro Koyama","doi":"10.4103/2045-9912.318858","DOIUrl":null,"url":null,"abstract":"<p><p>A relationship between Bifidobacterium and defecation has previously been reported. Our hypothesis on the effectiveness of alkaline electrolyzed water (AEW) proposes that ingestion of AEW, considered possessing antioxidative properties, increases the number of Bifidobacteria and improves stool hardness and gastrointestinal symptoms. A double-blind, randomized study was conducted to evaluate the connection between stool consistency and change in gut microbiota composition induced by drinking hydrogen-dissolved AEW. The participants drank 500 mL of purified tap water or AEW every day for 2 weeks. In this study, drinking AEW did not drastically change gut microbiota, but it appeared to act on a specific bacterial species. Drinking AEW was confirmed to cause an increase in Bifidobacterium. The AEW group also saw stool consistency significantly converge to Bristol stool scale Type 4 (\"normal\"). Therefore, it is highly likely that the gut microbiota will be changed by drinking AEW. This study was retrospectively registered in University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000039507) on February 18, 2020, and was approved by the Ethics Committee of University of Yamanashi (approval No. H30-25) on January 9, 2018.</p>","PeriodicalId":18559,"journal":{"name":"Medical Gas Research","volume":"11 4","pages":"138-144"},"PeriodicalIF":3.0000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/db/MGR-11-138.PMC8374459.pdf","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Gas Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2045-9912.318858","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 9

Abstract

A relationship between Bifidobacterium and defecation has previously been reported. Our hypothesis on the effectiveness of alkaline electrolyzed water (AEW) proposes that ingestion of AEW, considered possessing antioxidative properties, increases the number of Bifidobacteria and improves stool hardness and gastrointestinal symptoms. A double-blind, randomized study was conducted to evaluate the connection between stool consistency and change in gut microbiota composition induced by drinking hydrogen-dissolved AEW. The participants drank 500 mL of purified tap water or AEW every day for 2 weeks. In this study, drinking AEW did not drastically change gut microbiota, but it appeared to act on a specific bacterial species. Drinking AEW was confirmed to cause an increase in Bifidobacterium. The AEW group also saw stool consistency significantly converge to Bristol stool scale Type 4 ("normal"). Therefore, it is highly likely that the gut microbiota will be changed by drinking AEW. This study was retrospectively registered in University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000039507) on February 18, 2020, and was approved by the Ethics Committee of University of Yamanashi (approval No. H30-25) on January 9, 2018.

Abstract Image

查看原文本刊更多论文

摄入氢溶解碱性电解水对粪便稠度和肠道微生物群的影响:一项双盲随机试验。

双歧杆菌与排便之间的关系此前已有报道。我们对碱性电解水(AEW)有效性的假设提出，摄入被认为具有抗氧化特性的AEW，可以增加双歧杆菌的数量，改善粪便硬度和胃肠道症状。本研究采用双盲、随机研究的方法，对饮用氢溶AEW引起的粪便稠度与肠道菌群组成变化之间的关系进行了评价。参与者每天饮用500毫升净化自来水或AEW，持续两周。在这项研究中，饮用AEW并没有彻底改变肠道微生物群，但它似乎对一种特定的细菌起作用。饮用AEW被证实会导致双歧杆菌的增加。AEW组的粪便一致性也明显趋近于布里斯托尔粪便量表4型(“正常”)。因此，饮用AEW很可能会改变肠道菌群。本研究于2020年2月18日在大学医院医学信息网络(UMIN)临床试验注册中心(UMIN ID: UMIN000039507)回顾性注册，并经山梨县大学伦理委员会批准(批准号:2018年1月9日H30-25)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.