Drosophila melanogaster: a fruitful model for oncohistones.

IF 2.4 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fly Pub Date : 2021-12-01 DOI:10.1080/19336934.2020.1863124
Amel Chaouch, Paul Lasko
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引用次数: 0

Abstract

Drosophila melanogaster has proven to be a powerful genetic model to study human disease. Approximately 75% of human disease-associated genes have homologs in the fruit fly and regulatory pathways are highly conserved in Drosophila compared to humans. Drosophila is an established model organism for the study of genetics and developmental biology related to human disease and has also made a great contribution to epigenetic research. Many key factors that regulate chromatin condensation through effects on histone post-translational modifications were first discovered in genetic screens in Drosophila. Recently, the importance of chromatin regulators in cancer progression has been uncovered, leading to a rapid expansion in the knowledge on how perturbations of chromatin can result in the pathogenesis of human cancer. In this review, we provide examples of how Drosophila melanogaster has contributed to better understanding the detrimental effects of mutant forms of histones, called 'oncohistones', that are found in different human tumours.

Abstract Image

黑腹果蝇:嗜瘤蛋白丰富的模型。
黑腹果蝇已被证明是研究人类疾病的一个强有力的遗传模型。大约75%的人类疾病相关基因在果蝇中有同源基因,与人类相比,果蝇的调控途径高度保守。果蝇是与人类疾病相关的遗传学和发育生物学研究的既定模式生物,在表观遗传学研究方面也做出了巨大贡献。许多通过组蛋白翻译后修饰调节染色质凝聚的关键因素是在果蝇的遗传筛选中首次发现的。最近,染色质调节因子在癌症进展中的重要性已经被发现,导致染色质扰动如何导致人类癌症发病机制的知识迅速扩展。在这篇综述中,我们提供了一些例子,说明黑腹果蝇如何有助于更好地理解在不同的人类肿瘤中发现的组蛋白突变形式的有害影响,称为“癌组蛋白”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Fly
Fly 生物-生化与分子生物学
CiteScore
2.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: Fly is the first international peer-reviewed journal to focus on Drosophila research. Fly covers a broad range of biological sub-disciplines, ranging from developmental biology and organogenesis to sensory neurobiology, circadian rhythm and learning and memory, to sex determination, evolutionary biology and speciation. We strive to become the “to go” resource for every researcher working with Drosophila by providing a forum where the specific interests of the Drosophila community can be discussed. With the advance of molecular technologies that enable researchers to manipulate genes and their functions in many other organisms, Fly is now also publishing papers that use other insect model systems used to investigate important biological questions. Fly offers a variety of papers, including Original Research Articles, Methods and Technical Advances, Brief Communications, Reviews and Meeting Reports. In addition, Fly also features two unconventional types of contributions, Counterpoints and Extra View articles. Counterpoints are opinion pieces that critically discuss controversial papers questioning current paradigms, whether justified or not. Extra View articles, which generally are solicited by Fly editors, provide authors of important forthcoming papers published elsewhere an opportunity to expand on their original findings and discuss the broader impact of their discovery. Extra View authors are strongly encouraged to complement their published observations with additional data not included in the original paper or acquired subsequently.
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