The Interplay of Disease Modifying Anti Rheumatic Drugs and Tuberculin Skin Test.

IF 1.3 Q4 PHARMACOLOGY & PHARMACY

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-01-01 DOI:10.2174/1574884715999201231201538

Zia Abdullah, Arvind Kumar, M A Khan, Uma Kumar, Surabhi Vyas, Vishal K Vishwakarma, Piyush Ranjan, Ashutosh Biswas, Naveet Wig

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引用次数: 1

Abstract

Objective: The study was conducted to determine whether synthetic Disease-Modifying Anti Rheumatic Drugs (DMARDs) suppress the latency of Tuberculosis (TB) infection in Rheumatoid Arthritis (RA) patients along with other variables.

Methods: This was done through Tuberculin Skin Test (TST) using purified protein derivative (PPD) in a cohort of RA patients. The TST was taken positive when induration post-PPD injection was ≥ 5mm and negative or anergic when it was < 5mm. We included 100 patients (N = 100).

Results: The prevalence of positive TST was 36%, while 64% presented a negative result. Negative TST was significantly associated with steroid usage (39.4%, 95% CI: 28.4%-51.4%). Anergic (TST negative) and non-anergic (TST positive) patients were separated into groups, and a new analysis was conducted with elaboration on DMARDs used.

Conclusion: The use of steroids was associated with TST negativity, The same is not true with use of methotrexate or other DMARDs. Thus TST should be interpreted with caution, especially before starting biologicals.

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抗风湿药物与结核菌素皮肤试验的相互作用。

目的:研究合成抗风湿药物(DMARDs)是否能抑制类风湿关节炎(RA)患者结核(TB)感染的潜伏期及其他变量。方法:在一组RA患者中使用纯化蛋白衍生物(PPD)通过结核菌素皮肤试验(TST)完成。ppd注射后硬化≥5mm TST为阳性，< 5mm TST为阴性或无反应。我们纳入了100例患者(N = 100)。结果:TST阳性率为36%，阴性阳性率为64%。TST阴性与类固醇使用显著相关(39.4%，95% CI: 28.4%-51.4%)。将无反应(TST阴性)和非无反应(TST阳性)患者分为两组，并进行新的分析，详细说明使用的dmard。结论:使用类固醇与TST阴性相关，而使用甲氨蝶呤或其他DMARDs与TST阴性无关。因此，TST应谨慎解释，特别是在开始使用生物制剂之前。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Reviews in Clinical and Experimental Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

4.80

自引率

9.10%

发文量