Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kazim Sahin, Cemal Orhan, Osman Kucuk, Fusun Erten, Mehmet Tuzcu, Nurhan Sahin, Sara Perez Ojalvo, James Richard Komorowski
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引用次数: 1

Abstract

The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-α1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers.

补充生物酸镁对大鼠血清胰岛素、葡萄糖和脂质参数及肝蛋白脂质代谢水平的影响。
本研究的目的是研究一种新型生物素(生物酸镁)对大鼠血清葡萄糖、血脂和肝脏脂质代谢相关蛋白水平的影响。将42只大鼠分为6组,分别饲喂添加d-生物素(0.01、1或100 mg/kg BW)或生物酸镁(0.01、1或100 mg/kg BW)的标准蛋清粉饲粮,试验期35 d。两种生物素对血清葡萄糖和胰岛素浓度均无影响(p > 0.05)。血清总胆固醇和甘油三酯随生物素的增加而降低(p < 0.05)。与1 mg/kg剂量相比,生物酸镁的浓度较低(p < 0.05)。与d-生物素相比,生物酸镁组大鼠血清、肝脏、脑生物素和肝脏环鸟苷单磷酸(cGMP)浓度更高,特别是与1和100 mg/kg剂量组相比(p < 0.05)。两种生物素形式均降低肝脏SREBP-1c和FAS水平,升高AMPK-α1、ACC-1、ACC-2、PCC和MCC水平(p < 0.05)。生物酸镁的反应强度更强。与商业化的d-生物素相比,生物酸镁在降低血脂浓度和调节脂质代谢相关生物标志物的蛋白水平方面更有效。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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