Periostin deficiency attenuates lipopolysaccharide- and obesity-induced adipose tissue fibrosis.

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
FEBS Letters Pub Date : 2021-08-01 Epub Date: 2021-07-03 DOI:10.1002/1873-3468.14154
Yuhan Yang, Yanfei Zhang, Xueliang Zhou, Dandan Chen, Gaoliang Ouyang, Yingfu Liu, Dan Cui
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引用次数: 0

Abstract

Periostin (POSTN) is a type of matricellular protein, but its functions in adipose fibrosis remain unclear. Here, we found that POSTN expression is significantly increased in mouse adipose tissue after treatment with lipopolysaccharide (LPS) or a high-fat diet (HFD) and that adipose progenitor cells are the main source of POSTN. In our mouse model of fibrosis, POSTN deletion protected mice from adipose fibrosis, probably through reducing the accumulation of macrophages and promoting adipocyte differentiation of progenitor cells. Taken together, our study demonstrates that POSTN deficiency attenuates adipose tissue fibrosis and improves insulin resistance, providing new insights into the diagnosis and treatment of type II diabetes by targeting adipose tissue fibrosis.

包膜组织蛋白缺乏症可减轻脂多糖和肥胖诱导的脂肪组织纤维化。
Periostin(POSTN)是一种基质细胞蛋白,但其在脂肪纤维化中的功能尚不清楚。在这里,我们发现小鼠脂肪组织经脂多糖(LPS)或高脂饮食(HFD)处理后,POSTN的表达明显增加,而脂肪祖细胞是POSTN的主要来源。在我们的小鼠纤维化模型中,POSTN缺失可保护小鼠免于脂肪纤维化,这可能是通过减少巨噬细胞的积累和促进祖细胞的脂肪细胞分化实现的。综上所述,我们的研究表明,POSTN缺失可减轻脂肪组织纤维化并改善胰岛素抵抗,为通过靶向脂肪组织纤维化诊断和治疗II型糖尿病提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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