Is COVID-19 Fatality Rate Associated with Malaria Endemicity?

Abdul Rehman Arshad, Imtiaz Bashir, Farhat Ijaz, Nicholas Loh, Suraj Shukla, Ubaid Ur Rehman, Rana Khurram Aftab
{"title":"Is COVID-19 Fatality Rate Associated with Malaria Endemicity?","authors":"Abdul Rehman Arshad,&nbsp;Imtiaz Bashir,&nbsp;Farhat Ijaz,&nbsp;Nicholas Loh,&nbsp;Suraj Shukla,&nbsp;Ubaid Ur Rehman,&nbsp;Rana Khurram Aftab","doi":"10.15190/d.2020.17","DOIUrl":null,"url":null,"abstract":"<p><p>COVID-19 (coronavirus disease 2019) is a disease caused by the coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). COVID-19 has yielded many reported complications and unusual observations. In this article, we have reviewed one such observation: an association between malaria endemicity and reduced reported COVID-19 fatality. Malaria-endemic regions have a significantly lower reported COVID-19 fatality rate as compared to regions where malaria is non-endemic. Statistical analyses show that there is a strong negative correlation between the reported SARS-CoV-2 fatality and endemicity of malaria. In this review, we have discussed the potential role of CD-147, and potential malaria-induced immunity and polymorphisms in COVID-19 patients. Noteworthy, the results may also be due to underreported cases or due to the economic, political, and environmental differences between the malaria endemic and non-endemic countries. The study of this potential relationship might be of great help in COVID-19 therapy and prevention.</p>","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"8 4","pages":"e120"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749783/pdf/","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discoveries (Craiova, Romania)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15190/d.2020.17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6

Abstract

COVID-19 (coronavirus disease 2019) is a disease caused by the coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). COVID-19 has yielded many reported complications and unusual observations. In this article, we have reviewed one such observation: an association between malaria endemicity and reduced reported COVID-19 fatality. Malaria-endemic regions have a significantly lower reported COVID-19 fatality rate as compared to regions where malaria is non-endemic. Statistical analyses show that there is a strong negative correlation between the reported SARS-CoV-2 fatality and endemicity of malaria. In this review, we have discussed the potential role of CD-147, and potential malaria-induced immunity and polymorphisms in COVID-19 patients. Noteworthy, the results may also be due to underreported cases or due to the economic, political, and environmental differences between the malaria endemic and non-endemic countries. The study of this potential relationship might be of great help in COVID-19 therapy and prevention.

Abstract Image

Abstract Image

Abstract Image

COVID-19致死率与疟疾流行率有关吗?
COVID-19(冠状病毒病2019)是由冠状病毒SARS-CoV-2(严重急性呼吸综合征冠状病毒2)引起的疾病。COVID-19已经产生了许多报道的并发症和不寻常的观察结果。在本文中,我们回顾了其中一个观察结果:疟疾流行与报告的COVID-19死亡率降低之间的关联。与非疟疾流行地区相比,疟疾流行地区报告的COVID-19死亡率要低得多。统计分析表明,报告的SARS-CoV-2病死率与疟疾流行之间存在很强的负相关。在这篇综述中,我们讨论了CD-147的潜在作用,以及在COVID-19患者中潜在的疟疾诱导免疫和多态性。值得注意的是,这一结果也可能是由于少报病例,或由于疟疾流行国家和非流行国家之间的经济、政治和环境差异。研究这种潜在的关系可能对COVID-19的治疗和预防有很大的帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信