The Probable Association between Chronic Toxoplasma gondii Infection and Type 1 and Type 2 Diabetes Mellitus: A Case-Control Study.

Q3 Immunology and Microbiology

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-05-24 eCollection Date: 2021-01-01 DOI:10.1155/2021/2508780

Shahrzad Soltani, Sanaz Tavakoli, Mohamad Sabaghan, Mehdi Sagha Kahvaz, Marzieh Pashmforosh, Masoud Foroutan

{"title":"The Probable Association between Chronic Toxoplasma gondii Infection and Type 1 and Type 2 Diabetes Mellitus: A Case-Control Study.","authors":"Shahrzad Soltani, Sanaz Tavakoli, Mohamad Sabaghan, Mehdi Sagha Kahvaz, Marzieh Pashmforosh, Masoud Foroutan","doi":"10.1155/2021/2508780","DOIUrl":null,"url":null,"abstract":"Purpose: The probable association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus (DM) is still controversial, and there are several studies with conflicting results. Thus, this study was performed to assess the possible association between chronic T. gondii infection and type 1 diabetes mellitus (T1DM) and T2DM.Methods: In this case-control study, a total of 105 diabetic subjects including 36 patients with T1DM and 69 patients with T2DM were recruited. In addition, 150 nondiabetic subjects were enrolled as controls. Each case group had its own control group. Each participant completed a structured questionnaire obtaining demographic information. Serum samples were examined for T. gondii-specific IgG antibody using enzyme-linked immunosorbent assay (ELISA) method.Results: Analysis revealed that 69.4% and 34.0% of patients with T1DM and control subjects were serologically positive for T. gondii, respectively (odds ratio (OR): 4.41; 95% confidence interval (CI): 1.75-11.06; P=0.001). Moreover, 72.5% of T2DM patients and 29.0% of healthy individuals were seropositive for T. gondii (OR: 6.44; 95% CI: 3.25-12.74; P < 0.001). Among risk factors, only contact with cats was significantly associated with IgG seroprevalence in both T2DM patients (P < 0.001) and control subjects (P=0.045).Conclusion: Although the results showed that chronic T. gondii infection is significantly associated with T1DM and T2DM, there remain many questions regarding the exact mechanisms of T. gondii in the pathogenesis of DM.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"2508780"},"PeriodicalIF":0.0000,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169249/pdf/","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary Perspectives on Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2021/2508780","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Immunology and Microbiology","Score":null,"Total":0}

引用次数: 7

Abstract

Purpose: The probable association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus (DM) is still controversial, and there are several studies with conflicting results. Thus, this study was performed to assess the possible association between chronic T. gondii infection and type 1 diabetes mellitus (T1DM) and T2DM.

Methods: In this case-control study, a total of 105 diabetic subjects including 36 patients with T1DM and 69 patients with T2DM were recruited. In addition, 150 nondiabetic subjects were enrolled as controls. Each case group had its own control group. Each participant completed a structured questionnaire obtaining demographic information. Serum samples were examined for T. gondii-specific IgG antibody using enzyme-linked immunosorbent assay (ELISA) method.

Results: Analysis revealed that 69.4% and 34.0% of patients with T1DM and control subjects were serologically positive for T. gondii, respectively (odds ratio (OR): 4.41; 95% confidence interval (CI): 1.75-11.06; P=0.001). Moreover, 72.5% of T2DM patients and 29.0% of healthy individuals were seropositive for T. gondii (OR: 6.44; 95% CI: 3.25-12.74; P < 0.001). Among risk factors, only contact with cats was significantly associated with IgG seroprevalence in both T2DM patients (P < 0.001) and control subjects (P=0.045).

Conclusion: Although the results showed that chronic T. gondii infection is significantly associated with T1DM and T2DM, there remain many questions regarding the exact mechanisms of T. gondii in the pathogenesis of DM.

Abstract Image

查看原文本刊更多论文

慢性刚地弓形虫感染与1型和2型糖尿病的可能关系:一项病例对照研究

目的:弓形虫(T. gondii)感染与糖尿病(DM)之间的关系仍有争议，有几项研究结果相互矛盾。因此，本研究旨在评估慢性弓形虫感染与1型糖尿病(T1DM)和2型糖尿病之间可能存在的关联。方法:本病例对照研究共纳入糖尿病患者105例，其中T1DM患者36例，T2DM患者69例。此外，150名非糖尿病患者作为对照。每个病例组都有自己的对照组。每位参与者都完成了一份结构化的问卷，以获取人口统计信息。采用酶联免疫吸附试验(ELISA)检测血清中弓形虫特异性IgG抗体。结果:分析显示，T1DM患者弓形虫血清学阳性比例为69.4%，对照组为34.0%(优势比(OR): 4.41;95%置信区间(CI): 1.75-11.06;P = 0.001)。此外，72.5%的T2DM患者和29.0%的健康人血清弓形虫阳性(OR: 6.44;95% ci: 3.25-12.74;P < 0.001)。在危险因素中，只有与猫接触与T2DM患者(P < 0.001)和对照组(P=0.045) IgG血清阳性率显著相关。结论:虽然结果显示慢性弓形虫感染与T1DM和T2DM显著相关，但关于弓形虫在DM发病中的确切机制仍存在许多问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊