Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

IF 2.4 3区 医学 Q2 ANDROLOGY
Klaus-Peter Dieckmann, Osama Andura, Uwe Pichlmeier, Klaus Martin Otte, Hendrik Isbarn, Christian Wülfing
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引用次数: 3

Abstract

Background: The testis represents one place where the progenitor of vitamin D is converted into its active form. Loss of one testis was suggested to result in reduced vitamin D serum levels. Vitamin D deficiency would represent a significant health problem in the long-term course of patients with testicular germ cell tumors (GCTs) since most of them survive. The purpose of this study was to look to the serum 25(OH)-Vitamin D (25OHD) levels in patients with GCTs before and after orchiectomy. A total of 177 GCT patients underwent measurements of serum 25OHD levels, thereof 83 with preoperative measurements and 94 with measurements at six particular time-points from immediate postoperatively to >24 months. Longitudinal assessments of 25OHD serum levels were performed in individual patients with repeated measurements. A second analysis involved patient cohorts with measurements at six postoperative time-points. Serum levels of patients were also compared with 2 control groups, one consisting of 84 patients with non-neoplastic testicular diseases and another with 237 patients with non-neoplastic urologic diseases. We also looked to associations of 25OHD levels with levels of testosterone, follicle stimulating hormone (FSH), age, histology of GCT and season. Descriptive statistical methods were employed to compare groups and to analyze changes over time.

Results: Normal serum levels of 25OHD were found in 21.7%, 23.1%, 20.2%, 21.9% in GCT patients preoperatively, after >2 years, in control group 1 and control group 2, respectively. Levels were significantly higher in spring and summer, but no association was found with other parameters. We found a significant transient decrease of 25OHD levels with a nadir at 6-12 months after orchiectomy and a recovery thereafter.

Conclusion: Contrasting with previous studies we found no permanent reduction of serum 25OHD levels after orchiectomy but transient postoperative drop of 25OHD levels. There were no associations of 25OHD levels with age, and levels of testosterone or FSH. Our results may point to a particular role of the testis in vitamin D metabolism and may thus enhance the understanding of the diverse physiological roles of the testis.

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睾丸癌患者切除睾丸后血清25-羟基维生素D水平是否降低?
背景:睾丸是维生素D祖转化为活性形式的一个地方。有人认为,失去一个睾丸会导致血清维生素D水平降低。在睾丸生殖细胞肿瘤(gct)患者的长期病程中,维生素D缺乏将是一个重大的健康问题,因为大多数患者都存活了下来。本研究的目的是观察睾丸切除术前后gct患者血清25(OH)-维生素D (25OHD)水平。共有177例GCT患者进行了血清25OHD水平测量,其中83例为术前测量,94例为术后立即至>24个月的6个特定时间点测量。在重复测量的个体患者中进行25OHD血清水平的纵向评估。第二项分析涉及患者队列,在术后6个时间点进行测量。对照非肿瘤性睾丸疾病患者84例,泌尿系统非肿瘤性疾病患者237例。我们还研究了25OHD水平与睾酮水平、卵泡刺激素(FSH)水平、年龄、GCT组织学和季节的关系。描述性统计方法用于组间比较和分析随时间的变化。结果:GCT患者术前、>2年后、对照组1、对照组2血清25OHD水平正常的分别为21.7%、23.1%、20.2%、21.9%。在春季和夏季水平明显较高,但与其他参数没有关联。我们发现25OHD水平在睾丸切除术后6-12个月达到最低点,随后恢复。结论:与以往的研究相比,我们发现睾丸切除术后血清25OHD水平没有永久性下降,但术后25OHD水平有短暂下降。25OHD水平与年龄、睾丸激素或卵泡刺激素水平没有关联。我们的结果可能指出睾丸在维生素D代谢中的特殊作用,从而可能增强对睾丸多种生理作用的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Basic and Clinical Andrology
Basic and Clinical Andrology Medicine-Urology
CiteScore
3.50
自引率
0.00%
发文量
21
审稿时长
22 weeks
期刊介绍: Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.
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