Role and potential clinical utility of ARID1A in gastrointestinal malignancy

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation Research-Reviews in Mutation Research Pub Date : 2021-01-01 DOI:10.1016/j.mrrev.2020.108360

Ruihua Wang , Mei Chen , Xiaojun Ye , Karen Poon

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引用次数: 7

Abstract

ARID1A (AT-rich interactive domain 1A) is a newly discovered tumor suppressor gene, and its encoded product is an important component of the SWI/SNF chromatin remodeling complex. ARID1A plays an important role in cell proliferation, invasion and metastasis, apoptosis, cell cycle regulation, epithelial mesenchymal transition, and the regulation of other of biological behaviors. Recently, ARID1A mutations have been increasingly reported in esophageal adenocarcinoma, gastric cancer, colorectal cancer, hepatocellular carcinoma, cholangiocarcinoma, pancreatic cancer, and other malignant tumors of the digestive system. This article reviews the relationship between ARID1A mutation and the molecular mechanisms of carcinogenesis, including microsatellite instability and the PI3K/ATK signaling pathway, and relates these mechanisms to the prognostic assessment of digestive malignancy. Further, this review describes the potential for molecular pathologic epidemiology (MPE) to provide new insights into environment-tumor-host interactions.

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ARID1A在胃肠道恶性肿瘤中的作用和潜在临床应用

ARID1A (AT-rich interactive domain 1A)是新发现的肿瘤抑制基因，其编码产物是SWI/SNF染色质重塑复合体的重要组成部分。ARID1A在细胞增殖、侵袭转移、凋亡、细胞周期调控、上皮间质转化等生物学行为调控中发挥重要作用。近年来，ARID1A突变在食管癌、胃癌、结直肠癌、肝细胞癌、胆管癌、胰腺癌等消化系统恶性肿瘤中的报道越来越多。本文综述了ARID1A突变与肿瘤发生的分子机制，包括微卫星不稳定性和PI3K/ATK信号通路的关系，并将这些机制与消化道恶性肿瘤的预后评估联系起来。此外，本文还介绍了分子病理流行病学(MPE)为环境-肿瘤-宿主相互作用提供新见解的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.