Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics.

IF 1.8 4区化学 Q3 POLYMER SCIENCE

Designed Monomers and Polymers Pub Date : 2021-05-18 DOI:10.1080/15685551.2021.1929684

Hongmei Bi, Zeqin Chen, Jiaqin Qiu

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引用次数: 4

Abstract

Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers' fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn't affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems.

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磁性脂质微胶囊用于潜在癌症治疗的药物释放和磁热分析。

具有安全、稳定和优异磁热效应的磁性纳米颗粒是制备智能磁性药物载体和实现药物在特定靶点可控释放的前提条件。本研究通过实验分析和理论模拟，对两种磁性脂质微胶囊(MLMs)分别装载脂质包被MNPs和未包被MNPs的药物释放和磁热效应进行了深入的比较。模拟结果表明，脂包被与未包被MNPs之间存在几乎相同的磁热效应和温度升高，这与实验药物释放结果一致。在MNPs表面涂覆脂对MNPs的磁热和传热没有影响。由于MNPs与水、MLMs与周围水之间的热传递，整个样品溶液的温升低于MNPs本身的温升。本研究结果为开发健康、安全、具有生物相容性的给药系统提供了可靠的理论基础。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications