Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.

IF 4.7 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2021-06-01 DOI:10.1016/j.celrep.2021.109204

Chihiro Yoshihara, Kenichi Tokita, Teppo Maruyama, Misato Kaneko, Yousuke Tsuneoka, Kansai Fukumitsu, Eri Miyazawa, Kazutaka Shinozuka, Arthur J Huang, Katsuhiko Nishimori, Thomas J McHugh, Minoru Tanaka, Shigeyoshi Itohara, Kazushige Touhara, Kazunari Miyamichi, Kumi O Kuroda

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引用次数: 0

Abstract

Maternal mammals exhibit heightened motivation to care for offspring, but the underlying neuromolecular mechanisms have yet to be clarified. Here, we report that the calcitonin receptor (Calcr) and its ligand amylin are expressed in distinct neuronal populations in the medial preoptic area (MPOA) and are upregulated in mothers. Calcr+ MPOA neurons activated by parental care project to somatomotor and monoaminergic brainstem nuclei. Retrograde monosynaptic tracing reveals that significant modification of afferents to Calcr+ neurons occurs in mothers. Knockdown of either Calcr or amylin gene expression hampers risk-taking maternal care, and specific silencing of Calcr+ MPOA neurons inhibits nurturing behaviors, while pharmacogenetic activation prevents infanticide in virgin males. These data indicate that Calcr+ MPOA neurons are required for both maternal and allomaternal nurturing behaviors and that upregulation of amylin-Calcr signaling in the MPOA at least partially mediates risk-taking maternal care, possibly via modified connectomics of Calcr+ neurons postpartum.

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内侧视前区的降钙素受体信号传导有助于冒险的母性护理。

母性哺乳动物会表现出更强的照顾后代的动机，但其潜在的神经分子机制尚未明确。在这里，我们报告了降钙素受体（Calcr）及其配体淀粉样蛋白在内侧视前区（MPOA）不同的神经元群中表达，并在母体中上调。受父母照料激活的 Calcr+ MPOA 神经元可投射到躯体运动和单胺类脑干核。逆行单突触描记显示，在母体中，Calcr+神经元的传入发生了显著改变。Calcr或淀粉样蛋白基因表达的敲除会阻碍冒险的母性照顾，Calcr+ MPOA神经元的特异性沉默会抑制哺育行为，而药物基因激活会防止处男的杀婴行为。这些数据表明，Calcr+ MPOA神经元是母性和异体哺育行为所必需的，而且MPOA中淀粉样蛋白-Calcr信号的上调至少部分介导了冒险的母性照料行为，这可能是通过产后Calcr+神经元的连接组学改变实现的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.