Mechanobiology of T Cell Activation: To Catch a Bond.

IF 3.5 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
ACS Chemical Biology Pub Date : 2021-10-06 Epub Date: 2021-07-02 DOI:10.1146/annurev-cellbio-120219-055100
Baoyu Liu, Elizabeth M Kolawole, Brian D Evavold
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引用次数: 23

Abstract

T cell activation is a critical event in the adaptive immune response, indispensable for cell-mediated and humoral immunity as well as for immune regulation. Recent years have witnessed an emerging trend emphasizing the essential role that physical force and mechanical properties play at the T cell interface. In this review, we integrate current knowledge of T cell antigen recognition and the different models of T cell activation from the perspective of mechanobiology, focusing on the interaction between the T cell receptor (TCR) and the peptide-major histocompatibility complex (pMHC) antigen. We address the shortcomings of TCR affinity alone in explaining T cell functional outcomes and the rising status of force-regulated TCR bond lifetimes, most notably the TCR catch bond. Ultimately, T cell activation and the ensuing physiological responses result from mechanical interaction between TCRs and the pMHC.

T细胞活化的机械生物学:抓住一个键。
T细胞活化是适应性免疫反应中的一个关键事件,是细胞介导免疫和体液免疫以及免疫调节必不可少的。近年来出现了一种强调物理力和机械性能在T细胞界面上发挥重要作用的新兴趋势。在本文中,我们从机械生物学的角度,整合目前关于T细胞抗原识别的知识和T细胞活化的不同模型,重点关注T细胞受体(TCR)和肽-主要组织相容性复合体(pMHC)抗原之间的相互作用。我们解决了单独的TCR亲和力在解释T细胞功能结果和力调节TCR键寿命的上升地位方面的缺点,最值得注意的是TCR捕获键。最终,T细胞活化和随后的生理反应是由tcr和pMHC之间的机械相互作用引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Chemical Biology
ACS Chemical Biology 生物-生化与分子生物学
CiteScore
7.50
自引率
5.00%
发文量
353
审稿时长
3.3 months
期刊介绍: ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.
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