Role of Chest Computed Tomography versus Real Time Reverse Transcription Polymerase Chain Reaction for Diagnosis of COVID-19: A Systematic Review and Meta-Analysis.

Q3 Immunology and Microbiology

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-05-28 eCollection Date: 2021-01-01 DOI:10.1155/2021/8798575

Dina M Ali, Lamiaa G Zake, Nevine K El Kady

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引用次数: 2

Abstract

Background: The current global pandemic of COVID-19 is considered a public health emergency. The diagnosis of COVID-19 depends on detection of the viral nucleic acid by real time reverse transcription polymerase chain reaction (RT-PCR). However, false-negative RT-PCR tests are reported and could hinder the control of the pandemic. Chest computed tomography could achieve a more reliable diagnosis and represent a complementary diagnostic tool.

Aim: To perform a meta-analysis and systematic review to find out the role of chest computed tomography versus RT-PCR for precise diagnosis of COVID-19 infection.

Methods: We searched three electronic databases (PubMed, ScienceDirect, and Scopus) from April 1 to April 20, 2020, to find out articles including the accuracy of chest computed tomography scan versus RT-PCR for diagnosis of SARS-CoV-2 infection. Observational studies, case series, and case reports were included.

Results: A total of 238 articles were retrieved from the search strategy. Following screening, 39 articles were chosen for full text assessment and finally 35 articles were included for qualitative and quantitative analysis. Chest computed tomography showed a wide range of sensitivity varied from 12%-100%.

Conclusion: Chest computed tomography is playing a key role for diagnosis and detection of COVID-19 infection. Computed tomography image findings may precede the initially positive RT-PCR assay.

Abstract Image

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胸部计算机断层扫描与实时逆转录聚合酶链反应在COVID-19诊断中的作用:系统综述和荟萃分析

背景:当前的COVID-19全球大流行被视为突发公共卫生事件。COVID-19的诊断依赖于实时逆转录聚合酶链反应(RT-PCR)检测病毒核酸。然而，据报道，RT-PCR检测呈假阴性，这可能会阻碍对大流行的控制。胸部计算机断层扫描可以获得更可靠的诊断，并代表一个补充的诊断工具。目的:通过荟萃分析和系统评价，探讨胸部计算机断层扫描与RT-PCR在COVID-19感染精确诊断中的作用。方法:检索2020年4月1日至4月20日的PubMed、ScienceDirect和Scopus三个电子数据库，查找胸部计算机断层扫描与RT-PCR诊断SARS-CoV-2感染的准确性。包括观察性研究、病例系列和病例报告。结果:检索策略共检索到238篇文献。经筛选，选取39篇文章进行全文评估，最后纳入35篇文章进行定性和定量分析。胸部计算机断层扫描显示灵敏度范围从12%-100%不等。结论:胸部计算机断层扫描在COVID-19感染的诊断和检测中发挥着关键作用。计算机断层扫描图像发现可能先于最初的RT-PCR阳性检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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