Clinical Markers May Identify Patients at Risk for Early Parkinson's Disease Dementia: A Prospective Study.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2021-01-01 DOI:10.1177/15333175211021369

Anamaria Jurcau, Vharoon Sharma Nunkoo

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引用次数: 0

Abstract

Background: The study aims at identifying features predictive of early onset of dementia in Parkinson's disease (PD).

Methods: 103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.

Results: By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = -.621, p < 0.001) and insomnia (r = -.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).

Conclusion: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.

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临床标记物可识别早期帕金森氏症痴呆风险患者：一项前瞻性研究

研究背景研究旨在确定帕金森病（PD）早期痴呆症的预测特征。方法：对 103 名未痴呆的帕金森病患者进行基线各种量表评估，并对 89 名患者进行为期 3 年的随访：研究结束时，43.8%的患者出现痴呆。痴呆症的发生与基线迷你精神状态检查得分（皮尔逊系数 r = .404，p = 0.013）、是否存在自主神经功能障碍（r = -.621，p < 0.001）和失眠（r = -.526，p = 0.001）有关。二元逻辑回归分析显示，痴呆症的发生与自律神经功能失调（95% CI 2.60 至 52.83，p < 0.001）和失眠（95% CI 0.60 至 0.95，p = 0.017）密切相关：有自律神经功能紊乱和失眠症状的患者患痴呆症的风险较高，应更密切地监测其认知症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).