Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population.

IF 2.7 4区 医学 Q2 GENETICS & HEREDITY
Peng Xue, Haihong Cao, Zhimin Ma, Ying Zhou, Nian Wang
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引用次数: 2

Abstract

Objectives: To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population.

Methods: The Hardy-Weinberg equilibrium (HWE) and the relationship between TCF7L2 gene single nucleotide polymorphism (SNPs) and DN susceptibility were evaluated by SNPStats. The interaction among four SNPs and environmental factors were tested by generalized multifactor dimensionality reduction (GMDR). The consistency of cross validation, accuracy of test balance and sign test were calculated to evaluate the interaction of each selection. The logistic regression was used to test the interaction between rs7903146 and current smoking by stratified analysis.

Results: Logistic regression analysis indicated that the DN risk of rs7903146-T allele carriers were obviously higher than that in CC genotype carriers (CT + TT versus CC), adjusted OR (95 %CI) = 1.64 (1.24-2.06). However, we also discovered that people with rs12255372, rs11196205 and rs290487 minor allele had non-significant difference risk of DN compared with people with major allele. The GMDR model found a significant two-locus model (p = 0.0100) including rs7903146 and current smoking, suggesting a potential gene-environment interaction between rs7903146 and current smoking. Compared with never smokers with rs7903146- CC genotype, current smokers with rs7903146- CT or TT genotype had the highest DN risk. After covariate adjustment, OR (95 %CI) was 2.15 (1.58-2.78).

Conclusions: We found a significant relationship of rs7903146-T alleles, and the interaction between rs7903146-T and current smoking with increased DN risk.

转录因子7-样2基因与吸烟对中国汉族糖尿病肾病风险的相互作用。
目的:探讨转录因子7-样2 (TCF7L2)基因多态性与糖尿病肾病(DN)发病风险的关系,以及基因-环境相互作用对中国汉族糖尿病肾病发病风险的影响。方法:采用SNPStats分析Hardy-Weinberg平衡(HWE)和TCF7L2基因单核苷酸多态性(snp)与DN易感性的关系。采用广义多因素降维法(GMDR)检验4种snp与环境因子的相互作用。计算交叉验证的一致性、试验平衡的准确性和符号检验来评价各选择的相互作用。分层分析采用logistic回归检验rs7903146与吸烟现状的交互作用。结果:Logistic回归分析显示,rs7903146-T等位基因携带者的DN风险明显高于CC基因型携带者(CT + TT vs . CC),校正OR (95% CI) = 1.64(1.24 ~ 2.06)。然而,我们也发现携带rs12255372、rs11196205和rs290487小等位基因的人与携带主要等位基因的人相比,患DN的风险无显著差异。GMDR模型发现rs7903146与当前吸烟存在显著的双位点模型(p = 0.0100),提示rs7903146与当前吸烟存在潜在的基因-环境相互作用。与从未吸烟的rs7903146- CC基因型相比,目前吸烟者rs7903146- CT或TT基因型的DN风险最高。协变量调整后,OR (95% CI)为2.15(1.58-2.78)。结论:我们发现rs7903146-T等位基因,以及rs7903146-T与当前吸烟的相互作用与DN风险增加有显著关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genes and Environment
Genes and Environment Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
4.00
自引率
0.00%
发文量
24
审稿时长
27 weeks
期刊介绍: Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences. Topics published in the journal include, but are not limited to, mutagenesis and anti-mutagenesis in bacteria; genotoxicity in mammalian somatic cells; genotoxicity in germ cells; replication and repair; DNA damage; metabolic activation and inactivation; water and air pollution; ROS, NO and photoactivation; pharmaceuticals and anticancer agents; radiation; endocrine disrupters; indirect mutagenesis; threshold; new techniques for environmental mutagenesis studies; DNA methylation (enzymatic); structure activity relationship; chemoprevention of cancer; regulatory science. Genetic toxicology including risk evaluation for human health, validation studies on testing methods and subjects of guidelines for regulation of chemicals are also within its scope.
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