Long noncoding RNAs: role and contribution in pancreatic cancer.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Transcription-Austin Pub Date : 2021-02-01 Epub Date: 2021-05-26 DOI:10.1080/21541264.2021.1922071

K T Ramya Devi, Dharshene Karthik, TharunSelvam Mahendran, M K Jaganathan, Sanjana Prakash Hemdev

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引用次数: 8

Abstract

Noncoding RNAs are proclaimed to be expressed in various cancer types and one such type is found to be pancreatic ductal adenocarcinoma (PDAC). The long noncoding RNAs (LncRNAs) affect the migration, invasion, and growth of tumor cells by playing important roles in the process of epigenesis, post-transcription, and transcriptional regulation along with the maintenance of apoptosis and cell cycle. It is quite subtle whether the alterations in lncRNAs would impact PDAC progression and development. This review throws a spotlight on the lncRNAs associated with tumor functions: MALAT-1, HOTAIR, HOXA13, H19, LINC01559, LINC00460, SNHG14, SNHG16, DLX6-AS1, MSC-AS1, ABHD11-AS1, DUXAP8, DANCR, XIST, DLEU2, etc. are upregulated lncRNAs whereas GAS5, HMlincRNA717, MIAT, LINC01111, lncRNA KCNK15-AS1, etc. are downregulated lncRNAs inhibiting the invasion and progression of PDAC. These data provided helps in the assessment of lncRNAs in the development, metastasis, and occurrence of PDAC and also play a vital role in the evolution of biomarkers and therapeutic agents for the treatment of PDAC.

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长链非编码rna在胰腺癌中的作用和贡献。

非编码rna被认为在多种癌症类型中表达，其中一种类型是胰腺导管腺癌(PDAC)。长链非编码rna (long noncoding rna, LncRNAs)在肿瘤细胞的表观发生、转录后、转录调控等过程中发挥重要作用，并维持细胞凋亡和细胞周期，影响肿瘤细胞的迁移、侵袭和生长。lncrna的改变是否会影响PDAC的进展和发展尚不清楚。本文综述了与肿瘤功能相关的lncRNA: MALAT-1、HOTAIR、HOXA13、H19、LINC01559、LINC00460、SNHG14、SNHG16、DLX6-AS1、mscs - as1、ABHD11-AS1、DUXAP8、DANCR、XIST、dle2等为上调lncRNA，而GAS5、HMlincRNA717、MIAT、LINC01111、lncRNA KCNK15-AS1等为下调lncRNA，抑制PDAC的侵袭和进展。这些数据有助于评估lncrna在PDAC的发展、转移和发生中的作用，也对PDAC治疗的生物标志物和治疗药物的发展起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transcription-Austin BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

6.50

自引率

5.60%

发文量