Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-10 DOI:10.1080/13813455.2021.1933045

Laurie Isacco, Gaël Ennequin, Nathalie Boisseau

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引用次数: 2

Abstract

Context: Independently of the total body fat mass, upper body fat mass deposition is strongly associated with cardiometabolic comorbidities. The mechanisms underlying fat mass localisation are not fully understood, but evidences indicate sex-specific fat mass distribution. Currently, data on women are scarce and the link between hormonal status changes during their life and fat mass distribution is overlooked.

Method: For this narrative review, literature data were extracted from the PubMed and CENTRAL databases to examine the relationship between hormonal status and adipose tissue localisation in women.

Results: Menopause strongly influences fat mass localisation, while the effect of the menstrual cycle phases, oral contraception use and pregnancy has not been unambiguously determined.

Conclusion: Reliable data are lacking on the relationship between hormonal variations throughout the lifespan and body fat mass localisation in women. Future studies should take into account the hormonal status of women to reduce the risk of cardiometabolic diseases.

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女性一生中不同激素状态变化对脂肪块定位的影响:一项叙述性回顾。

背景:独立于全身脂肪量，上身脂肪量沉积与心脏代谢合并症密切相关。脂肪块定位的机制尚不完全清楚，但有证据表明，脂肪块分布具有性别特异性。目前，关于女性的数据很少，她们一生中荷尔蒙状态的变化和脂肪量分布之间的联系被忽视了。方法:在这篇叙述性综述中，从PubMed和CENTRAL数据库中提取文献数据，以检查女性激素状态和脂肪组织定位之间的关系。结果:更年期强烈影响脂肪块定位，而月经周期阶段、口服避孕药使用和怀孕的影响尚未明确确定。结论:缺乏关于女性一生中激素变化与体脂量定位之间关系的可靠数据。未来的研究应考虑到妇女的荷尔蒙状况，以降低患心脏代谢疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.