Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2021-06-12 DOI:10.1186/s40794-021-00140-8

Hussam Mousa, Ghada Salameh Mohammed Al-Bluwi, Zainab Fathi Mohammed Al Drini, Huda Imam Gasmelseed, Jamal Aldeen Alkoteesh, Zahir Osman Eltahir Babiker

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引用次数: 2

Abstract

Background: There is a dearth of information on liver abscesses in the United Arab Emirates. Herein, we describe the clinical features of liver abscesses and determine their incidence rates and clinical outcomes.

Methods: We retrospectively reviewed the clinical charts of adult patients with a primary diagnosis of liver abscess at a major hospital over a 7-year period.

Results: Amongst 45 patients, 82.2% (37/45) had a pyogenic liver abscess (PLA) and 17.8% (8/45) had amoebic liver abscesses (ALA). Overall, patients were young (median age 42 years, IQR 35-52), mostly males (77.8%, 35/45) from the Indian subcontinent (55.6%, 25/45), presented with fever (88.9%, 40/45) and abdominal pain (88.9%, 40/45), and had a solitary abscess on imaging (71.1% (32/45). Crude annual incidence rates were 35.9/100,000 hospital admissions (95% CI 26.2-48.0) and 5.9/100,000 inhabitants (95% CI 4.3-7.9). All ALA patients were from the Indian subcontinent (100%, 8/8). Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1-60.5%). The hospital stay was shorter in ALA (7.5 days, IQR 7-8.5) than in PLA (14 days, IQR 9-17). No deaths were recorded within 30 days of hospitalisation.

Conclusions: ALA was exclusively seen in migrants from the Indian subcontinent, suggesting importation. Further research to characterise K. pneumoniae isolates and assess potential risk factors is needed.

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溶组织内阿米巴的输入和肺炎克雷伯菌在肝脓肿中的优势:来自阿拉伯联合酋长国的7年回顾性队列研究。

背景:关于阿拉伯联合酋长国肝脓肿的信息缺乏。在此，我们描述肝脓肿的临床特征，并确定其发病率和临床结果。方法:我们回顾性分析了一家大医院7年来以肝脓肿为首发诊断的成年患者的临床资料。结果:45例患者中化脓性肝脓肿(PLA)占82.2%(37/45)，阿米巴性肝脓肿(ALA)占17.8%(8/45)。总体而言，患者年轻(中位年龄42岁，IQR 35-52)，大多数来自印度次大陆的男性(77.8%，35/45)(55.6%，25/45)，表现为发热(88.9%，40/45)和腹痛(88.9%，40/45)，影像学上有孤立性脓肿(71.1%，32/45)。粗年发病率为住院人数的35.9/10万(95% CI 26.2-48.0)和居民的5.9/10万(95% CI 4.3-7.9)。所有ALA患者均来自印度次大陆(100%，8/8)。肺炎克雷伯菌是PLA中最常见的病原体(43.2% [16/37]，95% CI 27.1 ~ 60.5%)。ALA组住院时间(7.5 d, IQR 7 ~ 8.5)短于PLA组(14 d, IQR 9 ~ 17)。住院30天内无死亡记录。结论:ALA仅见于来自印度次大陆的移民，提示输入性。需要进一步研究肺炎克雷伯菌分离株的特征并评估潜在的危险因素。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.