Potential Role of Perilacunar Remodeling in the Progression of Osteoporosis and Implications on Age-Related Decline in Fracture Resistance of Bone.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2021-08-01 Epub Date: 2021-06-12 DOI:10.1007/s11914-021-00686-8

Katharina Jähn-Rickert, Elizabeth A Zimmermann

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引用次数: 4

Abstract

Purpose of review: We took an interdisciplinary view to examine the potential contribution of perilacunar/canalicular remodeling to declines in bone fracture resistance related to age or progression of osteoporosis.

Recent findings: Perilacunar remodeling is most prominent as a result of lactation; recent advances further elucidate the molecular players involved and their effect on bone material properties. Of these, vitamin D and calcitonin could be active during aging or osteoporosis. Menopause-related hormonal changes or osteoporosis therapies affect bone material properties and mechanical behavior. However, investigations of lacunar size or osteocyte TRAP activity with age or osteoporosis do not provide clear evidence for or against perilacunar remodeling. While the occurrence and potential role of perilacunar remodeling in aging and osteoporosis progression are largely under-investigated, widespread changes in bone matrix composition in OVX models and following osteoporosis therapies imply osteocytic maintenance of bone matrix. Perilacunar remodeling-induced changes in bone porosity, bone matrix composition, and bone adaptation could have significant implications for bone fracture resistance.

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骨腔周围重构在骨质疏松症进展中的潜在作用以及与年龄相关的骨抗骨折能力下降的意义。

综述的目的:我们采用跨学科的观点来研究与年龄或骨质疏松症进展相关的骨腔周围/骨小管重塑对骨折抵抗能力下降的潜在贡献。最近的研究发现:由于哺乳期，腔旁重构最为突出;近年来的研究进展进一步阐明了相关分子及其对骨材料性能的影响。其中，维生素D和降钙素在衰老或骨质疏松症期间可能很活跃。与更年期相关的激素变化或骨质疏松症治疗影响骨材料的性质和力学行为。然而，对腔隙大小或骨细胞TRAP活性与年龄或骨质疏松的研究并不能提供支持或反对腔隙周围重构的明确证据。虽然在衰老和骨质疏松进展中的发生和潜在作用在很大程度上尚未得到充分研究，但OVX模型和骨质疏松治疗后骨基质成分的广泛变化意味着骨基质的骨细胞维持。骨臼周围重塑引起的骨孔隙度、骨基质组成和骨适应性的变化可能对骨折抵抗有重要影响。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.