A mitochondrial gatekeeper that helps cells escape death by ferroptosis

IF 48.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Pub Date : 2021-05-12 DOI:10.1038/d41586-021-01203-8

Javier Garcia-Bermudez, Kıvanç Birsoy

引用次数: 23

Abstract

Ferroptosis is a type of cell death driven by oxidative damage to lipid membranes. The discovery that organelles called mitochondria have an antioxidant system that counteracts ferroptosis might lead to new anticancer therapies. Pathway found that combats lipid peroxidation of mitochondrial membranes.

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一种线粒体守门员，可帮助细胞摆脱因铁蛋白沉积而死亡的命运

铁细胞凋亡是一种由脂质膜氧化损伤导致的细胞死亡。发现线粒体这种细胞器具有一种抗氧化系统，可以抵消铁氧化作用，这可能会带来新的抗癌疗法。发现对抗线粒体膜脂质过氧化的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature 综合性期刊-综合性期刊

CiteScore

90.00

自引率

1.20%

发文量

3652

审稿时长

3 months

期刊介绍： Nature is a prestigious international journal that publishes peer-reviewed research in various scientific and technological fields. The selection of articles is based on criteria such as originality, importance, interdisciplinary relevance, timeliness, accessibility, elegance, and surprising conclusions. In addition to showcasing significant scientific advances, Nature delivers rapid, authoritative, insightful news, and interpretation of current and upcoming trends impacting science, scientists, and the broader public. The journal serves a dual purpose: firstly, to promptly share noteworthy scientific advances and foster discussions among scientists, and secondly, to ensure the swift dissemination of scientific results globally, emphasizing their significance for knowledge, culture, and daily life.