Reduction-sensitive N, N'-Bis(acryloyl) cystinamide-polymerized Nanohydrogel as a Potential Nanocarrier for Paclitaxel Delivery.

IF 1.8 4区化学 Q3 POLYMER SCIENCE

Designed Monomers and Polymers Pub Date : 2021-04-18 DOI:10.1080/15685551.2021.1914398

Linna Yu, Lingping Kong, Junpeng Xie, Wei Wang, Chen Chang, Hongli Che, Mingzhe Liu

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引用次数: 0

Abstract

Novel monomer, N, N'-bis(acryloyl) cystinamide (NBACA), was designed and synthesized with L-cystine as row material. By using this NBACA both as the monomer and crosslinker, reduction-sensitive nanohydrogel was prepared in ethanol via distillation-precipitation polymerization. The obtained nanohydrogel can provide a relatively hydrophobic environment and hydrogen-bonding sites inside the gel; therefore, it is suitable for loading hydrophobic drug. When paclitaxel that possess poor water-solubility was used as a model drug, the nanohydrogel represented a high drug-loading capacity, and dispersed well in aqueous solutions. Furthermore, the disulfide-group-containing nanohydrogel exhibited good reduction-sensitive drug-release behavior. The nanohydrogel biodegraded rapidly in a reducing environment, and released approximately 80% of the PTX within 24 h. Cytotoxicity assays showed that the PTX-loaded nanohydrogel exhibited high cytotoxicity against MCF-7 breast cancer cells, while blank nanohydrogels displayed a negligible cytotoxicity.

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对还原敏感的 N,N'-双（丙烯酰）胱氨酰胺聚合纳米水凝胶作为紫杉醇递送的潜在纳米载体

以 L-胱氨酸为原料，设计并合成了新型单体 N，N'-双（丙烯酰）胱氨酰胺（NBACA）。利用这种 NBACA 作为单体和交联剂，在乙醇中通过蒸馏沉淀聚合法制备了还原敏感性纳米水凝胶。得到的纳米水凝胶可以在凝胶内部提供相对疏水的环境和氢键位点，因此适合负载疏水性药物。当以水溶性较差的紫杉醇为模型药物时，纳米水凝胶具有较高的药物负载能力，在水溶液中分散良好。此外，含二硫键的纳米水凝胶还表现出良好的还原敏感性药物释放行为。细胞毒性实验表明，负载 PTX 的纳米水凝胶对 MCF-7 乳腺癌细胞具有很高的细胞毒性，而空白纳米水凝胶的细胞毒性则微乎其微。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications