Preclinical Studies and Clinical Prospects of Wharton's Jelly-Derived MSC for Treatment of Acute Radiation Syndrome.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2021-01-01 Epub Date: 2021-04-28 DOI:10.1007/s40778-021-00188-4

Mayuri Bandekar, Dharmendra K Maurya, Deepak Sharma, Santosh K Sandur

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引用次数: 3

Abstract

Purpose of review: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have received widespread attention from researchers owing to the remarkable benefits offered by these cells over other stem cells. The primitive nature of WJ-MSCs, ease of isolation, differentiation ability, and immuno-modulatory nature make these cells superior to bone marrow MSCs and ideal to treat various human ailments. This review explores ability of WJ-MSCs to mitigate acute radiation syndrome caused by planned or unplanned radiation exposure.

Recent findings: Recent reports suggest that WJ-MSCs home to damaged tissues in irradiated host and mitigate radiation induced damage to radiosensitive tissues such as hematopoietic and gastrointestinal systems. WJ-MSCs and conditioned media were found to protect mice from radiation induced mortality and also prevent radiation dermatitis. Local irradiation-induced lung toxicity in mice was significantly reduced by CXCR4 over-expressing WJ-MSCs.

Summary: Emerging evidences support safety and effectiveness of WJ-MSCs for treatment of acute radiation syndrome and lung injury after planned or accidental exposure. Additionally, conditioned media collected after culturing WJ-MSCs can also be used for mitigation of radiation dermatitis. Clinical translation of these findings would be possible after careful evaluation of resilience, effectiveness, and molecular mechanism of action of xenogeneic WJ-MSCs in non-human primates.

Abstract Image

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沃顿果冻源MSC治疗急性放射综合征的临床前研究和临床前景。

综述目的:Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs)由于其与其他干细胞相比具有显著的益处而受到了研究人员的广泛关注。WJ-MSCs的原始性质、易于分离、分化能力和免疫调节性质使这些细胞优于骨髓MSCs，是治疗各种人类疾病的理想选择。本文探讨WJ-MSCs减轻计划或计划外辐射暴露引起的急性辐射综合征的能力。最近的研究发现:最近的报道表明，WJ-MSCs可以在受辐射的宿主中修复受损组织，并减轻辐射引起的对辐射敏感组织(如造血和胃肠道系统)的损伤。发现WJ-MSCs和条件培养基具有保护小鼠免受辐射致死和预防放射性皮炎的作用。过表达CXCR4的WJ-MSCs可显著降低小鼠局部辐射诱导的肺毒性。总结:新出现的证据支持WJ-MSCs治疗急性辐射综合征和计划或意外暴露后肺损伤的安全性和有效性。此外，培养WJ-MSCs后收集的条件培养基也可用于缓解放射性皮炎。在仔细评估异种WJ-MSCs在非人灵长类动物中的恢复力、有效性和分子作用机制后，这些发现的临床转化将是可能的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.