Flavonolignan 2, 3-dehydroderivatives from Oenanthe javanica and their anti inflammatory activities.

Abstract

Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C (1-3) and nine known flavonolignan derivatives (4-12) were isolated from Oenanthe javanica. Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates (1-12) on RAW264.7 macrophage cells were investigated. Three new compounds (1-3) demonstrated anti inflammatory activity with IC₅₀ values ranging from 6.5 ± 0.6 to 14.7 ± 1.6 µM. Furthermore, two compounds (11 and 12) demonstrated moderate anti inflammatory activity, with IC₅₀ values ranging from 24.1 ± 1.2 to 62.5 ± 1.9 µM.