Study on hypoxia-inducible factor and its roles in immune system.

IF 2.7 Q3 IMMUNOLOGY
Immunological Medicine Pub Date : 2021-12-01 Epub Date: 2021-04-25 DOI:10.1080/25785826.2021.1910187
Ali Asghar Kiani, Hossein Elyasi, Shadiyeh Ghoreyshi, Negar Nouri, Ali Safarzadeh, Amirhossein Nafari
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引用次数: 7

Abstract

The Hypoxia-Inducible Factor-1 (HIF-1) is a dimeric protein complex that plays a significant role in responding to low oxygen or hypoxia concentrations. Chronic inflammation is one of the immune system responses and can increase HIF expression in involved tissues through lowering the oxygen and hypoxia. The HIF factor has many critical roles in immunity, and thus, we reviewed the crucial roles of this factor in the immune system. The results showed various key roles on the immune system, including physical defenses, innate immune (neutrophils apoptosis, macrophages) and inflammatory responses (pyrexia and local heat, iron access, etc.), upregulation in response to microbial infections, cytokines expression (IL-1, IL-2, IL-6, IL-8, IL-12, IL-18, TNF, etc.), drug targeting, etc. The HIF roles in the acquired immune system include: enhance the adaptation of cells (dendritic cells) to new conditions and triggering the signal pathways. The findings of the present review demonstrated that the HIF has important roles in the immune system, including physical defense, innate immune as well as acquired immunity; therefore, it may be considered as a potent drug targeting several diseases such as cancers, infectious diseases, etc.

缺氧诱导因子及其在免疫系统中的作用研究。
缺氧诱导因子-1 (HIF-1)是一种二聚体蛋白复合物,在应对低氧或缺氧浓度中起重要作用。慢性炎症是免疫系统反应之一,可通过降低氧和缺氧水平,增加HIF在相关组织中的表达。HIF因子在免疫系统中具有许多重要作用,因此,我们综述了该因子在免疫系统中的重要作用。结果显示其在免疫系统中具有多种关键作用,包括物理防御、先天免疫(中性粒细胞凋亡、巨噬细胞)和炎症反应(发热和局部热、铁通道等)、对微生物感染的反应上调、细胞因子表达(IL-1、IL-2、IL-6、IL-8、IL-12、IL-18、TNF等)、药物靶向等。HIF在获得性免疫系统中的作用包括:增强细胞(树突状细胞)对新条件的适应和触发信号通路。本综述的研究结果表明,HIF在免疫系统中具有重要作用,包括物理防御、先天免疫和获得性免疫;因此,它可以被认为是一种针对多种疾病的有效药物,如癌症、传染病等。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunological Medicine
Immunological Medicine Medicine-Immunology and Allergy
CiteScore
7.10
自引率
2.30%
发文量
19
审稿时长
19 weeks
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