A Facile Synthesis of Nido-Carborane Polymers via Dynamic Self-Assembly by Poly(carboxybetaine methacrylate).

Zhou Wang
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引用次数: 0

Abstract

Carborane are widely applied in boron neutron capture therapy (BNCT) field, but it is difficult to perform biocompatibility with cells due to its own water solubility differences, so how to solve the water solubility problem has always been the focus of research. A simple, inexpensive and effective method was used to study the synthesis of nido-carborane azaspirodecanium poly(carboxybetaine methacrylate) by one-pot cyclization of nido-carborane azaspirodecanium under the synergistic effect of inorganic bases and conventional organic solvents. Its characterization is mainly to use 1H-NMR nuclear magnetic resonance spectrum and infrared spectroscopy to determine the characteristic peak and range of borane. Through transmission electron microscope (TEM), it can be observed that the white nanoparticles, namely carborane, are completely contained by polymer ions, which not only increases the surface area but also the concentration of boron uptake in the cell is 100 times that of borono-phenylalanine (BPA). Based on the successful synthesis of N-CB5-4 and N-CB6-5 without harsh conditions, a feasibility point of view was put forward, namely, super water-soluble carborane polymer.

聚甲基丙烯酸羧酸甜菜碱动态自组装法快速合成奈多-碳硼烷聚合物。
碳硼烷广泛应用于硼中子俘获治疗(BNCT)领域,但由于其自身的水溶性差异,难以与细胞进行生物相容性,因此如何解决其水溶性问题一直是研究的重点。采用一种简单、廉价、有效的方法,在无机碱和常规有机溶剂的协同作用下,将氮杂环碳硼烷一锅环化合成氮杂环十二烷聚甲基丙烯酸羧甜菜碱。其表征主要是利用1H-NMR核磁共振谱和红外光谱来确定硼烷的特征峰和范围。通过透射电镜(TEM)可以观察到,白色纳米粒子即碳硼烷被聚合物离子完全包裹,不仅增加了表面积,而且细胞内硼的吸收浓度是硼苯丙氨酸(BPA)的100倍。在成功合成N-CB5-4和N-CB6-5的基础上,提出了一种可行性观点,即超水溶性碳硼烷聚合物。
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来源期刊
Journal of nanoscience and nanotechnology
Journal of nanoscience and nanotechnology 工程技术-材料科学:综合
自引率
0.00%
发文量
0
审稿时长
3.6 months
期刊介绍: JNN is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. JNN publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, theory and computation, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology.
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